Bisphosphonate Therapy and Atypical Fractures

被引：31
作者：
Saleh, Anas [1 ]
Hegde, Vishal V. [2 ]
Potty, Anish G. [1 ]
Lane, Joseph M. [1 ]
机构：
[1] Hosp Special Surg, Dept Orthopaed Surg, New York, NY 10021 USA
[2] Cornell Univ, Weill Cornell Med Coll, New York, NY 10021 USA
来源：
ORTHOPEDIC CLINICS OF NORTH AMERICA | 2013年 / 44卷 / 02期
关键词：
Bisphosphonate therapy; Atypical fractures; Osteoporosis; Atypical femoral fractures; SUPPRESSED BONE TURNOVER; FEMORAL-SHAFT FRACTURES; NITROGEN-CONTAINING BISPHOSPHONATES; SUBTROCHANTERIC STRESS-FRACTURES; DIAPHYSEAL FEMUR FRACTURES; VITAMIN-D SUPPLEMENTATION; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE; CORTICAL BONE; MICRODAMAGE ACCUMULATION;
D O I：
10.1016/j.ocl.2013.01.001
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Atypical femoral fractures have attracted a great deal of attention and controversy in the osteoporosis community because of their association with prolonged bisphosphonate therapy. The purpose of this article is to review the epidemiologic evidence linking bisphosphonates to atypical fractures and to highlight the potential pathologic mechanisms involved in such fractures. A management plan is provided based on the available evidence.
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收藏
页码：137 / +
页数：16
相关论文
共 94 条
  • [1] Cumulative Alendronate Dose and the Long-Term Absolute Risk of Subtrochanteric and Diaphyseal Femur Fractures: A Register-Based National Cohort Analysis
    Abrahamsen, Bo
    Eiken, Pia
    Eastell, Richard
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (12) : 5258 - 5265
  • [2] Abrahamsen B, 2009, J BONE MINER RES, V24, P1095, DOI [10.1359/JBMR.081247, 10.1359/jbmr.081247]
  • [3] Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment
    Allen, Matthew R.
    Burr, David B.
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (11) : 1759 - 1765
  • [4] Raloxifene enhances vertebral mechanical properties independent of bone density
    Allen, Matthew R.
    Iwata, Ken
    Sato, Masahiko
    Burr, David B.
    [J]. BONE, 2006, 39 (05) : 1130 - 1135
  • [5] Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate
    Allen, Matthew R.
    Iwata, Ken
    Phipps, Roger
    Burr, David B.
    [J]. BONE, 2006, 39 (04) : 872 - 879
  • [6] Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures
    Andreassen, TT
    Ejersted, C
    Oxlund, H
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (06) : 960 - 968
  • [7] Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone
    Andreassen, TT
    Fledelius, C
    Ejersted, C
    Oxlund, H
    [J]. ACTA ORTHOPAEDICA SCANDINAVICA, 2001, 72 (03): : 304 - 307
  • [8] [Anonymous], 2011, FOOD ADVISORY COMMIT
  • [9] Teriparatide for Acceleration of Fracture Repair in Humans: A Prospective, Randomized, Double-Blind Study of 102 Postmenopausal Women With Distal Radial Fractures
    Aspenberg, Per
    Genant, Harry K.
    Johansson, Torsten
    Nino, Antonio J.
    See, Kyoungah
    Krohn, Kelly
    Garcia-Hernandez, Pedro A.
    Recknor, Christopher P.
    Einhorn, Thomas A.
    Dalsky, Gail P.
    Mitlak, Bruce H.
    Fierlinger, Anke
    Lakshmanan, Mark C.
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (02) : 404 - 414
  • [10] POSTTRANSLATIONAL MODIFICATIONS IN THE COLLAGEN OF HUMAN OSTEOPOROTIC FEMORAL-HEAD
    BAILEY, AJ
    WOTTON, SF
    SIMS, TJ
    THOMPSON, PW
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 185 (03) : 801 - 805
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