Hierarchically mesoporous Ce-based MOFs with enhanced alkaline phosphatase-like activity for phosphorylated biomarker sensing

被引：32

作者：

Gao, Rui ^{[1
]}

Ye, Niru ^{[1
]}

Kou, Xiaoxue ^{[1
]}

Shen, Yujian ^{[1
]}

Yang, Huangsheng ^{[1
]}

Wu, Tong ^{[1
]}

Huang, Siming ^{[2
,3
,4
]}

Chen, Guosheng ^{[1
]}

Ouyang, Gangfeng ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Peoples R China

[2] Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Mol, NMPA, Guangzhou 511436, Peoples R China

[3] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Peoples R China

[4] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 91期

基金：

中国国家自然科学基金;

关键词：

Diagnosis;

D O I：

10.1039/d2cc04895g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we develop a hierarchically mesoporous cerium metal-organic framework (Ce-HMMOF) nanozyme with enhanced ALP-mimicking activity for the naked-eye detection of phosphorylated biomarkers. The long-range ordered mesochannels (9.18 nm) throughout the Ce-HMMOF promote both the mass transfer and the accessibility of interior active sites, permitting the rapid and sensitive sensing of phosphorylated biomarkers through ALP-like biocatalysis. This work provides a new insight into the engineering of highly active nanozymes for disease-associated biomarker screening and diagnosis.

引用

页码：12720 / 12723

页数：4

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