Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma with Multiple Metastases and Elevated Serum Carcinoembryonic Antigen Level

被引：12

作者：

Kuo, Chin-Sung ^{[1
,4
]}

Tang, Kam-Tsun ^{[1
,4
]}

Lin, Jiun-Dian ^{[5
,6
]}

Yang, An-Hang ^{[2
,4
]}

Lee, Chen-Hsen ^{[3
,4
]}

Lin, Hong-Da ^{[1
,4
]}

机构：

[1] Taipei Vet Gen Hosp, Div Endocrinol & Metab, Dept Med, Taipei 11217, Taiwan

[2] Taipei Vet Gen Hosp, Dept Pathol, Taipei 11217, Taiwan

[3] Taipei Vet Gen Hosp, Dept Surg, Taipei 11217, Taiwan

[4] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[5] Shuang Ho Hosp, Div Endocrinol & Metab, Taipei, Taiwan

[6] Taipei Med Univ, Sch Med, Taipei, Taiwan

来源：

THYROID | 2012年 / 22卷 / 11期

关键词：

SINGLE INSTITUTION; PROGNOSIS; CANCER; FEATURES; I-131;

D O I：

10.1089/thy.2011.0361

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) is a rare variant of papillary thyroid carcinoma (PTC). We report a 61-year-old female of DSPC whose course was complicated by multiple metastases and an elevated serum carcinoembryonic antigen (CEA) level. Summary: The patient presented with upper back pain. X-ray showed an osteolytic lesion of the sixth cervical spinous process. She had a hard, nonmovable mass with fixed enlarged lymph nodes (LNs) over right neck. Fine-needle aspiration cytology revealed PTC with LNs metastasis. Positron emission tomography demonstrated multiple brain, bone, liver, and lung metastases. However, the patient had an elevated serum CEA level. She underwent a total thyroidectomy and 200 mCi radioactive 131 I therapy. The pathological findings were diffuse sclerosing variant of PTC with capsular and lymph vessel invasion. A double staining of tumor specimen appeared concomitantly positive for CEA and thyroglobulin. Conclusions: To our knowledge, DSPC with an elevated CEA level is extremely rare.

引用

页码：1187 / 1190

页数：4

共 27 条

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