Beyond H2S and NO Interplay: Hydrogen Sulfide and Nitroprusside React Directly to Give Nitroxyl (HNO). A New Pharmacological Source of HNO

被引：103

作者：

Filipovic, Milos R. ^{[1
]}

Eberhardt, Mirjam ^{[1
,2
]}

Prokopovic, Vladimir ^{[1
]}

Mijuskovic, Ana ^{[3
]}

Orescanin-Dusic, Zorana ^{[3
]}

Reeh, Peter ^{[2
]}

Ivanovic-Burmazovic, Ivana ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Physiol & Pathophysiol, D-91054 Erlangen, Germany

[3] Univ Belgrade, Inst Biol Res Sinisa Stankov, Belgrade, Serbia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 56卷 / 04期

关键词：

GENE-RELATED PEPTIDE; NITRIC-OXIDE; SODIUM-NITROPRUSSIDE; CENTER-DOT; CARDIOVASCULAR-SYSTEM; METAL NITROSYLS; S-NITROSOTHIOLS; IN-VIVO; COMPLEX; CHEMISTRY;

D O I：

10.1021/jm3012036

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hydrogen sulfide (H2S) has been increasingly recognized as an important signaling molecule that regulates both blood pressure and neuronal activity. Attention has been drawn to its interactions with another gasotransmitter, nitric oxide (NO). Here, we provide evidence that the physiological effects observed upon the application of sodium nitroprusside (SNP) and H2S can be ascribed to the generation of nitroxyl (HNO), which is a direct product of the reaction between SNP and H2S, not a consequence of released NO subsequently reacting with H2S. Intracellular HNO formation has been confirmed, and the subsequent release of calcitonin gene related peptide from a mouse heart has been demonstrated. Unlike with other thiols, SNP reacts with H2S in the same way as rhodanese, i.e, the cyanide transforms into a thiocyanate. These findings shed new light on how H2S is understood to interact with nitroprusside. Additionally, they offer a new and convenient pharmacological source of HNO for therapeutic purposes.

引用

页码：1499 / 1508

页数：10

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