Association of Ki67 index with prognosis for intermediate-grade canine cutaneous mast cell tumours*

被引:48
作者
Maglennon, G. A. [1 ]
Murphy, S. [1 ]
Adams, V. [1 ]
Miller, J. [1 ]
Smith, K. [1 ]
Blunden, A. [1 ]
Scase, T. J. [1 ]
机构
[1] Anim Hlth Trust, Newmarket CB8 7UU, Suffolk, England
关键词
canine; Ki67; mast cell tumour; prognosis;
D O I
10.1111/j.1476-5829.2008.00168.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Intermediate-grade mast cell tumours (MCT) represent a heterogeneous population of tumours. The prognosis for the majority of dogs is excellent following surgical excision, but a minority die because of their disease. A previous study identified Ki67 expression as a predictor of prognosis in all three grades of MCT. The purpose of this study was to validate those results in a new group of dogs, with intermediate-grade MCT only. Ki67 immunohistochemistry was performed on intermediate-grade MCT from 163 dogs with known outcome. Digital microscopy images were taken from each tumour, and an index calculated of Ki67-positive cells. Ki67 index as a binary variable with a cut-off value of 1.8% was confirmed to be associated with prognosis (hazard ratio = 19.1, P < 0.0001) for this cohort of dogs. The 1-year, 2-year and 3-year survival probabilities (with standard errors) of 127 dogs with a Ki67 index <= 1.8% were [0.95 (0.024), similar for all] and for 36 dogs with a Ki67 index > 1.8% were 0.54 (0.100), 0.45 (0.101) and 0.33 (0.104), respectively.
引用
收藏
页码:268 / 274
页数:7
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