Analysis of Codon Usage Patterns of Tianfu Goose Interferon Alpha

被引：1

作者：

Liu, Fei ^{[1
]}

Gao, Liqin ^{[1
]}

Cheng, Anchun ^{[1
]}

Wang, Mingshu ^{[1
]}

Han, Qinglin ^{[1
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan 625014, Sichuan, Peoples R China

来源：

2011 INTERNATIONAL CONFERENCE ON ENVIRONMENT SCIENCE AND BIOTECHNOLOGY (ICESB 2011) | 2011年 / 8卷

关键词：

Tianfu goose IFN-alpha; codon usage; analysis; comparison; SYNONYMOUS CODON; UNICELLULAR ORGANISMS; RESPECTIVE CODONS; ESCHERICHIA-COLI; PROTEIN GENES; TRANSFER-RNAS; BIAS; EXPRESSION; ABUNDANCE; SELECTION;

D O I：

10.1016/j.proenv.2011.10.111

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interferons(IFNs) are a large family of cytokines, belonging to glycoproteins. As for the antiviral and antineoplastic activity of IFNs, IFNs were widely studied. Based of recent gene sequence analyses, we found that codon usages were variation in different IFN genes. Codon usage in a sample of 5 genes from the interferon alpha has been analysed using multivariate statistical analysis. Goose and duck IFN-alpha gene shared the similar patterns, and differ from chicken IFN-alpha gene codon usage biases pattern. In other words, goose and duck had a much closer relationship than chicken. Asn(L), His(H), Ala(A) and Pro(P) were the preferred amino acids. RSCU values of 25 codons were greater than 1.0, and these codons had a much higher frequency of occurrence. In the accordance with the comparison, E. coli was much suitable for the expression of Tianfu goose IFN-alpha gene than Yeast and Human system. (C) 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of the Asia-Pacific Chemical, Biological & Environmental Engineering Society (APCBEES)

引用

页码：730 / 736

页数：7

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