Studies on possible protection against snake venom using Mucuna pruriens protein immunization

被引：23
作者：
Aguiyi, JC [1 ]
Igweh, AC
Egesie, UG
Leoncini, R
机构：
[1] Univ Jos, Dept Pharmacol & Clin Pharm, Jos, Nigeria
[2] NITR, Dept Biochem & Therapeut, Vom, Nigeria
[3] Univ Jos, Dept Physiol, Jos, Nigeria
[4] Univ Siena, Ist Biochim & Enzimol, I-53100 Siena, Italy
来源：
FITOTERAPIA | 1999年 / 70卷 / 01期
关键词：
Mucuna pruriens; immunization; cobra venom;
D O I：
10.1016/S0367-326X(98)00004-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Immunization against cobra venom using Mucuna pruriens derived serum immunoglobulins was carried out in a mouse model. The neutralizing ability of circulating antibodies was assessed by challenging the immunized mice with a minimum lethal dose of purified venom after 4, 24, 72 and 168 h. The single injection of the antibody preparation produced a high and sustained immune response with high survival rates of treated animals. (C) 1999 Elsevier Science B.V. All rights reserved.
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页码：21 / 24
页数：4
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