ERG Protein Expression in Human Tumors Detected With a Rabbit Monoclonal Antibody

被引：29
作者：
Yaskiv, Oksana [2 ]
Rubin, Brian P. [2 ]
He, Huiying [2 ,3 ]
Falzarano, Sara [2 ]
Magi-Galluzzi, Cristina [2 ]
Zhou, Ming [1 ,2 ]
机构：
[1] NYU, Langone Med Ctr, Dept Pathol, New York, NY 10016 USA
[2] Cleveland Clin, Dept Anat Pathol, Pathol & Lab Med Inst, Cleveland, OH 44106 USA
[3] Beijing Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2012年 / 138卷 / 06期
关键词：
ERG; Vascular lesion; Prostate carcinoma; Meningioma; Immunohistochemistry; GROWTH-FACTOR RECEPTOR-3; ETS GENE FUSIONS; TRANSCRIPTION FACTOR; PROSTATE-CANCER; MATRIX METALLOPROTEINASE-2; VASCULAR TUMORS; REARRANGEMENT; TMPRSS2-ERG; SPECIFICITY; MARKER;
D O I：
10.1309/AJCP3K5VUFALZTKC
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Avian v-ets erythroblastosis virus E26 oncogene homolog (ERG) is highly sensitive and specific for endothelial neoplasms and specific for prostate carcinoma. We characterized a rabbit anti-ERG antibody as an immunohistochemical agent to detect ERG expression in various tumors using tissue microarrays with a wide array of epithelial and mesenchymal tumors. ERG was positive in 63 (38%) of 168 prostate carcinomas and negative in all other epithelial tumors. ERG was positive in all 125 vascular lesions. It was also positive in the sarcomatoid component of a high-grade urothelial carcinoma and 6 (40%) of 15 meningiomas. Twelve (80%) of 15 meningiomas were positive for Fli1, including all 6 ERG-positive cases. Positive immunostaining with this antibody is therefore highly specific for prostate carcinoma and vascular lesions, with a few caveats. ERG is rarely detected in nonvascular mesenchymal tumors with this antibody. Furthermore, about 40% of meningiomas are also positive for ERG immunohistochemically, probably because of cross-reactivity with Fli1.
引用
收藏
页码：803 / 810
页数：8
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