Laboratory Assessment of Patients with Suspected Rheumatic Musculoskeletal Diseases: Challenges and Pitfalls

被引：6

作者：

Carubbi, Francesco ^{[1
,2
]}

Alunno, Alessia ^{[3
]}

Cipriani, Paola ^{[1
]}

Bistoni, Onelia ^{[3
]}

Scipioni, Rosa ^{[2
]}

Liakouli, Valiki ^{[1
]}

Ruscitti, Piero ^{[1
]}

Berardicurti, Onorina ^{[1
]}

Di Bartolomeo, Salvatore ^{[1
]}

Gerli, Roberto ^{[3
]}

Giacomelli, Roberto ^{[1
]}

机构：

[1] Univ Aquila, Sch Med, Dept Biotechnol & Appl Clin Sci, Rheumatol Unit, Laquila, Italy

[2] ASL1 Avezzano Sulmona Aquila, Dept Med, Laquila, AQ, Italy

[3] Univ Perugia, Dept Med, Rheumatol Unit, Perugia, PG, Italy

来源：

CURRENT RHEUMATOLOGY REVIEWS | 2019年 / 15卷 / 01期

关键词：

Laboratory; assessment; rheumatology; biomarkers; pathogenesis; mechanistic value; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; CITRULLINATED PEPTIDE ANTIBODIES; INTERNATIONAL CONSENSUS STATEMENT; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PRIMARY SJOGRENS-SYNDROME; SYNOVIAL-FLUID; CLASSIFICATION CRITERIA; BACTERIAL-INFECTION; RHEUMATOLOGY/EUROPEAN LEAGUE; PROCALCITONIN MEASUREMENT;

D O I：

10.2174/1573397114666180320113603

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current patient care in rheumatology relies primarily on a combination of traditional clinical assessment and standard laboratory tests. Investigators seek to discover new biomarkers and novel technologies to boost the research in this field. Mechanistic biomarkers such as cytokines, cell types, antibodies, signaling molecules, are rooted in the mechanism underlying the disease and can guide the clinical management of the disease. Conversely, descriptive biomarkers are by-products of the disease process, depict the state of a disease but are not involved in its pathogenesis. In this article, we reviewed the field of common laboratory biomarkers in rheumatology, highlighting both their descriptive or mechanistic value as well as their role in clinical practice.

引用

页码：27 / 43

页数：17

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