Laboratory Assessment of Patients with Suspected Rheumatic Musculoskeletal Diseases: Challenges and Pitfalls

被引：6

作者：

Carubbi, Francesco ^{[1
,2
]}

Alunno, Alessia ^{[3
]}

Cipriani, Paola ^{[1
]}

Bistoni, Onelia ^{[3
]}

Scipioni, Rosa ^{[2
]}

Liakouli, Valiki ^{[1
]}

Ruscitti, Piero ^{[1
]}

Berardicurti, Onorina ^{[1
]}

Di Bartolomeo, Salvatore ^{[1
]}

Gerli, Roberto ^{[3
]}

Giacomelli, Roberto ^{[1
]}

机构：

[1] Univ Aquila, Sch Med, Dept Biotechnol & Appl Clin Sci, Rheumatol Unit, Laquila, Italy

[2] ASL1 Avezzano Sulmona Aquila, Dept Med, Laquila, AQ, Italy

[3] Univ Perugia, Dept Med, Rheumatol Unit, Perugia, PG, Italy

来源：

CURRENT RHEUMATOLOGY REVIEWS | 2019年 / 15卷 / 01期

关键词：

Laboratory; assessment; rheumatology; biomarkers; pathogenesis; mechanistic value; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; CITRULLINATED PEPTIDE ANTIBODIES; INTERNATIONAL CONSENSUS STATEMENT; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PRIMARY SJOGRENS-SYNDROME; SYNOVIAL-FLUID; CLASSIFICATION CRITERIA; BACTERIAL-INFECTION; RHEUMATOLOGY/EUROPEAN LEAGUE; PROCALCITONIN MEASUREMENT;

D O I：

10.2174/1573397114666180320113603

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current patient care in rheumatology relies primarily on a combination of traditional clinical assessment and standard laboratory tests. Investigators seek to discover new biomarkers and novel technologies to boost the research in this field. Mechanistic biomarkers such as cytokines, cell types, antibodies, signaling molecules, are rooted in the mechanism underlying the disease and can guide the clinical management of the disease. Conversely, descriptive biomarkers are by-products of the disease process, depict the state of a disease but are not involved in its pathogenesis. In this article, we reviewed the field of common laboratory biomarkers in rheumatology, highlighting both their descriptive or mechanistic value as well as their role in clinical practice.

引用

页码：27 / 43

页数：17

共 153 条

[131] SYNOVIAL-FLUID TESTS - WHAT SHOULD BE ORDERED [J].

SHMERLING, RH ;

DELBANCO, TL ;

TOSTESON, ANA ;

TRENTHAM, DE .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 264 (08) :1009-1014

[132]

SHMERLING RH, 1994, RHEUM DIS CLIN N AM, V20, P503

[133] Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative [J].

Sivera, Francisca ;

Andres, Mariano ;

Carmona, Loreto ;

Kydd, Alison S. R. ;

Moi, John ;

Seth, Rakhi ;

Sriranganathan, Melonie ;

van Durme, Caroline ;

van Echteld, Irene ;

Vinik, Ophir ;

Wechalekar, Mihir D. ;

Aletaha, Daniel ;

Bombardier, Claire ;

Buchbinder, Rachelle ;

Edwards, Christopher J. ;

Landewe, Robert B. ;

Bijlsma, Johannes W. ;

Branco, Jaime C. ;

Burgos-Vargas, Ruben ;

Catrina, Anca I. ;

Elewaut, Dirk ;

Ferrari, Antonio J. L. ;

Kiely, Patrick ;

Leeb, Burkhard F. ;

Montecucco, Carlomaurizio ;

Mueller-Ladner, Ulf ;

Ostergaard, Mikkel ;

Zochling, Jane ;

Falzon, Louise ;

van der Heijde, Desiree M. .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (02) :328-335

[134] Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles [J].

Snir, O. ;

Widhe, M. ;

von Spee, C. ;

Lindberg, J. ;

Padyukov, L. ;

Lundberg, K. ;

Engstrom, A. ;

Venables, P. J. ;

Lundeberg, J. ;

Holmdahl, R. ;

Klareskog, L. ;

Malmstrom, V. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (05) :736-743

[135] Antibodies to Several Citrullinated Antigens Are Enriched in the Joints of Rheumatoid Arthritis Patients [J].

Snir, Omri ;

Widhe, Mona ;

Hermansson, Monika ;

von Spee, Caroline ;

Lindberg, Johan ;

Hensen, Sanne ;

Lundberg, Karin ;

Engstrom, Ake ;

Venables, Patrick J. W. ;

Toes, Rene E. M. ;

Holmdahl, Rikard ;

Klareskog, Lars ;

Malmstrom, Vivianne .

ARTHRITIS AND RHEUMATISM, 2010, 62 (01) :44-52

[136] Anti-dsDNA and Antichromatin Antibody Isotypes in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus [J].

Steiman, Amanda J. ;

Urowitz, Murray B. ;

Ibanez, Dominique ;

Li, Timothy T. ;

Gladman, Dafna D. ;

Wither, Joan .

JOURNAL OF RHEUMATOLOGY, 2015, 42 (05) :810-816

[137] Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus [J].

Stohl, William ;

Hiepe, Falk ;

Latinis, Kevin M. ;

Thomas, Mathew ;

Scheinberg, Morton A. ;

Clarke, Ann ;

Aranow, Cynthia ;

Wellborne, Frank R. ;

Abud-Mendoza, Carlos ;

Hough, Douglas R. ;

Pineda, Lilia ;

Migone, Thi-Sau ;

Zhong, Z. John ;

Freimuth, William W. ;

Chatham, W. Winn .

ARTHRITIS AND RHEUMATISM, 2012, 64 (07) :2328-2337

[138] Complement in the immunopathogenesis of rheumatic disease [J].

Sturfelt, Gunnar ;

Truedsson, Lennart .

NATURE REVIEWS RHEUMATOLOGY, 2012, 8 (08) :458-468

[139]

Sun J, 2014, CLIN EXP RHEUMATOL, V32, P11

[140] Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study [J].

Syversen, S. W. ;

Goll, G. L. ;

van der Heijde, D. ;

Landewe, R. ;

Lie, B. A. ;

Odegard, S. ;

Uhlig, T. ;

Gaarder, P. I. ;

Kvien, T. K. .

ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (02) :345-351

← 7 8 9 10 11 12 13 14 15 16 →