Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4

被引：68

作者：

Zhang, Yongjie ^{[1
]}

Zhang, Xia ^{[1
]}

Wang, Xi ^{[1
]}

Gan, Lu ^{[1
]}

Yu, Guanzhen ^{[1
]}

Chen, Ying ^{[2
]}

Liu, Ke ^{[1
]}

Li, Ping ^{[1
]}

Pan, Jun ^{[1
]}

Wang, Jiejun ^{[1
]}

Qin, Shukui ^{[3
]}

机构：

[1] Changzheng Hosp, Dept Oncol, Shanghai 200003, Peoples R China

[2] Changhai Hosp, Dept Pathol, Shanghai 200000, Peoples R China

[3] Eighty First Hosp, Canc Ctr PLA, Nanjing 210002, Jiangsu, Peoples R China

来源：

CANCER LETTERS | 2012年 / 321卷 / 01期

关键词：

Intestinal-type gastric cancer; LDH-A; Oct4; HDAC1; PLURIPOTENT STEM-CELLS; HYPOXIA-INDUCIBLE FACTORS; LACTATE-DEHYDROGENASE; AEROBIC GLYCOLYSIS; HUMAN FIBROBLASTS; EXPRESSION; MOUSE; INDUCTION; TRANSCRIPTION; NANOG;

D O I：

10.1016/j.canlet.2012.03.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many tumors metabolise the majority of the glucose that they take up through glycolysis even in the presence of an adequate oxygen supply. Lactate dehydrogenase A (LDH-A) is the critical enzyme that catalyses the transformation of pyruvate to lactate. We demonstrate that LDH-A reduction can suppress the tumorigenicity of intestinal-type gastric cancer (ITGC) cells by downregulating Oct4 both in vitro and in vivo. A statistical analysis of 661 ITGC specimens showed a significant correlation between LDH-A and Oct4 expression. Moreover, patients with low LDH-A/negative Oct4 expression exhibited better overall survival than patients with other combinations. We conclude that the close correlation of LDH-A and Oct4 may offer a promising therapeutic strategy for ITGC. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：45 / 54

页数：10

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