Pathogenesis and pathophysiology of endometriosis

被引：1161

作者：

Burney, Richard O. ^{[2
]}

Giudice, Linda C. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA

[2] Madigan Healthcare Syst, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Tacoma, WA USA

来源：

FERTILITY AND STERILITY | 2012年 / 98卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Endometriosis; pathogenesis; pathophysiology; lesion biology; MATRIX-METALLOPROTEINASE EXPRESSION; MIGRATION INHIBITORY FACTOR; ENDOTHELIAL GROWTH-FACTOR; TUMOR-NECROSIS-FACTOR; CHRONIC PELVIC PAIN; QUALITY-OF-LIFE; PERITONEAL-FLUID; STROMAL CELLS; AROMATASE EXPRESSION; INFERTILE WOMEN;

D O I：

10.1016/j.fertnstert.2012.06.029

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Originally described over three hundred years ago, endometriosis is classically defined by the presence of endometrial glands and stroma in extrauterine locations. Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential to the development of novel diagnostic and treatment approaches for this debilitating condition. (Fertil Steril (R) 2012; 98: 511-9. (C) 2012 by American Society for Reproductive Medicine.)

引用

页码：511 / 519

页数：9

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