Inhibiting HMGB1 Reduces Cerebral Ischemia Reperfusion Injury in Diabetic Mice

被引：35
作者：
Wang, Chong [1 ,2 ]
Jiang, Jie [2 ]
Zhang, Xiuping [3 ]
Song, Linjie [3 ]
Sun, Kai [4 ]
Xu, Ruxiang [1 ,5 ]
机构：
[1] Mil Gen Hosp Beijing, PLA, Beijing 100700, Peoples R China
[2] Jining First People Hosp, Jining 272011, Peoples R China
[3] Jinan Cent Hosp, Jinan 250012, Peoples R China
[4] Weifang Med Univ, Grad Sch, Weifang 261053, Peoples R China
[5] Gen Hosp Beijing, Affiliated Bayi Brain Hosp, Mil Reg, 5 Nanmencang, Beijing 100000, Peoples R China
来源：
INFLAMMATION | 2016年 / 39卷 / 06期
关键词：
HMGB1; brain ischemia reperfusion; diabetes mellitus; MOBILITY GROUP BOX-1; BLOOD-BRAIN-BARRIER; STROKE; RATS; INFLAMMATION; INTERLEUKIN-6; RECEPTOR; PROTEIN; NEUROINFLAMMATION; HYPERGLYCEMIA;
D O I：
10.1007/s10753-016-0418-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
High mobility group box1 (HMGB1) promotes inflammatory injury, and accumulating evidence suggests that it plays a key role in brain ischemia reperfusion (I/R), as well as the development of diabetes mellitus (DM). The purpose of this study was to investigate whether HMGB1 plays a role in brain I/R in a DM mouse model. Diabetes mellitus was induced by a high-calorie diet and streptozotocin treatment, and cerebral ischemia was induced by middle cerebral artery occlusion. We examined HMGB1 levels following cerebral I/R injury in DM and non-DM mice and evaluated the influence of altered HMGB1 levels on the severity of cerebral injury. Serum HMGB1 levels and the inflammatory factors IL-1 beta, IL-6, and inflammation-related enzyme iNOS were significantly elevated in DM mice with brain I/R compared with non-DM mice with brain I/R. Blocking HMGB1 function by intraperitoneal injection of anti-HMGB1 neutralizing antibodies reversed the inflammatory response and the extent of brain damage, suggesting that HMGB1 plays an important role in cerebral ischemic stroke in diabetic mice.
引用
收藏
页码：1862 / 1870
页数：9
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