The Role of Bacterial Vaginosis and Trichomonas in HIV Transmission Across The Female Genital Tract

被引：68

作者：

Mirmonsef, Paria ^{[1
]}

Krass, Laurie ^{[1
]}

Landay, Alan ^{[1
]}

Spear, Gregory T. ^{[1
]}

机构：

[1] Rush Univ, Med Ctr, Dept Immunol Microbiol, Chicago, IL 60612 USA

来源：

CURRENT HIV RESEARCH | 2012年 / 10卷 / 03期

关键词：

Bacterial vaginosis; HIV; Inflammation; Trichomonas vaginalis; IMMUNODEFICIENCY-VIRUS TYPE-1; SEXUALLY-TRANSMITTED INFECTIONS; NF-KAPPA-B; 2001-2004; NATIONAL-HEALTH; CHAIN FATTY-ACIDS; VAGINALIS INFECTION; MONOCARBOXYLATE TRANSPORTER; INFLAMMATORY RESPONSES; WOMEN; FLORA;

D O I：

10.2174/157016212800618165

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial vaginosis (BV) and Trichomonas vaginalis (TV) infections are both very common and are associated with increased risk of sexual transmission of HIV. There are several mechanisms by which BV and TV could affect susceptibility including inducing pro-inflammatory cytokines and disrupting mucosal barrier function. This review highlights recent advances in our understanding of how these genital conditions lead to an increased risk of HIV infection in women.

引用

页码：202 / 210

页数：9

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