ERBBs in the gastrointestinal tract: Recent progress and new perspectives

被引：31

作者：

Fiske, William H. ^{[1
]}

Threadgill, David ^{[4
,5
]}

Coffey, Robert J. ^{[1
,2
,3
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN 37232 USA

[3] Dept Vet Affairs Med Ctr, Nashville, TN 37232 USA

[4] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC 27599 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2009年 / 315卷 / 04期

关键词：

ERBBs; Colorectal cancer; Menetrier's disease; EPIDERMAL-GROWTH-FACTOR; EGF RECEPTOR TRANSACTIVATION; INTESTINAL EPITHELIAL-CELLS; FACTOR-RELATED PEPTIDES; HUMAN GASTRIC-CANCER; PROTEIN-KINASE-C; HELICOBACTER-PYLORI INFECTION; FACTOR-ALPHA; GENE AMPLIFICATION; MICE LACKING;

D O I：

10.1016/j.yexcr.2008.10.043

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The gastrointestinal epithelium does much more than provide a physical barrier between the intestinal lumen and our internal milieu. It is actively engaged in absorption and secretion of salt and water via ion transporters, exchangers and selective ion channels. It is also a continuously self-renewing epithelium that undergoes ordered growth and differentiation along its vertical axis. From this dual perspective, we will consider the actions of the ERBB family of ligands and receptors in the maintenance of gastrointestinal homeostasis and discuss instances when the actions of this family go awry such as in cancer and Menetrier's disease. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：583 / 601

页数：19

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