Reducing the risk of hyperammonemia from transfusion of stored red blood cells

被引：6

作者：

Apushkin, Marsha ^{[1
]}

Das, Anne ^{[1
]}

Joseph, Cherilyn ^{[1
]}

Leung, Edward Ki Yun ^{[1
]}

Yeo, Kiang-Teck J. ^{[1
]}

Baron, Joseph M. ^{[2
]}

Baron, Beverly W. ^{[1
]}

机构：

[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2013年 / 49卷 / 03期

关键词：

Ammonia in red cell units; Ammonia during red cell storage; Ammonia reduction by washing RBCs; Ammonia reduction by volume reduction of RBCs; STORAGE;

D O I：

10.1016/j.transci.2013.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ammonia concentration increases in red cell units (RBCs) during storage. We measured absolute amounts of ammonia (AA) per unit serially in stored RBCs and before and after removal of the supernatant by volume reduction (VR) or washing. Ammonia increased 6.4-fold in untreated units over 31 days. VR decreased AA 3.7-fold, whereas washing decreased it 38-fold (p < 0.0001). At least for certain patients, e.g., infants receiving large volume transfusions and patients in liver failure, it may be advisable to use RBCs as fresh as possible and to limit infusion (by VR or washing) of ammonia in the supernatant. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：459 / 462

页数：4

共 11 条

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