Posttranscriptional Regulation of Insulin Family Ligands and Receptors

被引:14
作者
Panda, Amaresh C. [1 ]
Grammatikakis, Ioannis [1 ]
Yoon, Je-Hyun [1 ]
Abdelmohsen, Kotb [1 ]
机构
[1] NIA, Genet Lab, Intramural Res Program, NIH, Baltimore, MD 21224 USA
关键词
glucose homeostasis; insulin-like growth factor; insulin-like growth factor receptor; RNA-binding protein; micro RNA; long noncoding RNA; mRNA decay; mRNA translation; insulin signaling; alternative splicing IRES; GROWTH-FACTOR-I; MESSENGER-RNA STABILITY; SQUAMOUS-CELL CARCINOMA; TRACT-BINDING PROTEIN; POLYPYRIMIDINE-TRACT; SKELETAL-MUSCLE; SPLICE-VARIANT; TRANSLATION INITIATION; UNTRANSLATED REGION; PANCREATIC-ISLETS;
D O I
10.3390/ijms140919202
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Insulin system including ligands (insulin and IGFs) and their shared receptors (IR and IGFR) are critical regulators of insulin signaling and glucose homeostasis. Altered insulin system is associated with major pathological conditions like diabetes and cancer. The mRNAs encoding for these ligands and their receptors are posttranscriptionally controlled by three major groups of regulators; (i) alternative splicing regulatory factors; (ii) turnover and translation regulator RNA-binding proteins (TTR-RBPs); and (iii) non-coding RNAs including miRNAs and long non-coding RNAs (lncRNAs). In this review, we discuss the influence of these regulators on alternative splicing, mRNA stability and translation. Due to the pathological impacts of insulin system, we also discussed the possibilities of discovering new potential regulators which will improve understanding of insulin system and associated diseases.
引用
收藏
页码:19202 / 19229
页数:28
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