Insulin system including ligands (insulin and IGFs) and their shared receptors (IR and IGFR) are critical regulators of insulin signaling and glucose homeostasis. Altered insulin system is associated with major pathological conditions like diabetes and cancer. The mRNAs encoding for these ligands and their receptors are posttranscriptionally controlled by three major groups of regulators; (i) alternative splicing regulatory factors; (ii) turnover and translation regulator RNA-binding proteins (TTR-RBPs); and (iii) non-coding RNAs including miRNAs and long non-coding RNAs (lncRNAs). In this review, we discuss the influence of these regulators on alternative splicing, mRNA stability and translation. Due to the pathological impacts of insulin system, we also discussed the possibilities of discovering new potential regulators which will improve understanding of insulin system and associated diseases.
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Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Ascano, Manuel, Jr.
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Mukherjee, Neelanjan
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Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Mukherjee, Neelanjan
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Bandaru, Pradeep
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机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Bandaru, Pradeep
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Miller, Jason B.
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机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Miller, Jason B.
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Nusbaum, Jeffrey D.
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Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Nusbaum, Jeffrey D.
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Corcoran, David L.
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机构:
Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Corcoran, David L.
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Langlois, Christine
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机构:
Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Program Early & Recurrent Pregnancy Loss, Bronx, NY 10461 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Langlois, Christine
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Munschauer, Mathias
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机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Munschauer, Mathias
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Dewell, Scott
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Rockefeller Univ, Genom Resource Ctr, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Dewell, Scott
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Hafner, Markus
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Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Hafner, Markus
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Williams, Zev
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Ohler, Uwe
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机构:
Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Ohler, Uwe
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Tuschl, Thomas
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机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
机构:
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
机构:
Univ N Carolina, Div Med Chem & Nat Prod, Eshelman Sch Pharm, Chapel Hill, NC 27515 USAUniv N Carolina, Div Med Chem & Nat Prod, Eshelman Sch Pharm, Chapel Hill, NC 27515 USA
Bonifacio, Laura N.
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Jarstfer, Michael B.
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Univ N Carolina, Div Med Chem & Nat Prod, Eshelman Sch Pharm, Chapel Hill, NC 27515 USAUniv N Carolina, Div Med Chem & Nat Prod, Eshelman Sch Pharm, Chapel Hill, NC 27515 USA
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Ascano, Manuel, Jr.
;
Mukherjee, Neelanjan
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Mukherjee, Neelanjan
;
Bandaru, Pradeep
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Bandaru, Pradeep
;
Miller, Jason B.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Miller, Jason B.
;
Nusbaum, Jeffrey D.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Nusbaum, Jeffrey D.
;
Corcoran, David L.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Corcoran, David L.
;
Langlois, Christine
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Program Early & Recurrent Pregnancy Loss, Bronx, NY 10461 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Langlois, Christine
;
Munschauer, Mathias
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Munschauer, Mathias
;
Dewell, Scott
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Genom Resource Ctr, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Dewell, Scott
;
Hafner, Markus
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Hafner, Markus
;
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Williams, Zev
;
Ohler, Uwe
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
Ohler, Uwe
;
Tuschl, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USARockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
机构:
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
机构:
Univ N Carolina, Div Med Chem & Nat Prod, Eshelman Sch Pharm, Chapel Hill, NC 27515 USAUniv N Carolina, Div Med Chem & Nat Prod, Eshelman Sch Pharm, Chapel Hill, NC 27515 USA
Bonifacio, Laura N.
;
Jarstfer, Michael B.
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h-index: 0
机构:
Univ N Carolina, Div Med Chem & Nat Prod, Eshelman Sch Pharm, Chapel Hill, NC 27515 USAUniv N Carolina, Div Med Chem & Nat Prod, Eshelman Sch Pharm, Chapel Hill, NC 27515 USA