A meta-analytic review of the CYP2A6 genotype and smoking behavior

被引:38
作者
Carter, BL [1 ]
Long, TY [1 ]
Cinciripini, PM [1 ]
机构
[1] Univ Texas, Dept Behav Sci, Unit 243, MD Anderson Canc Ctr, Houston, TX 77030 USA
关键词
D O I
10.1080/14622200410001676387
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Individuals who carry variant alleles of the CYP2A6 gene are poor metabolizers of nicotine and are believed to be more sensitive to nicotine's aversive effects than those with normal alleles. This sensitivity is hypothesized to exert a protective effect against smoking initiation and lead to lower cigarette consumption among smokers with variant alleles. Although early studies found an association between variant CYP2A6 alleles and smoking behavior, more recent studies have not. A meta-analysis was conducted to help resolve these conflicting results. A literature search produced 11 studies providing information on CYP2A6 genotyping in smokers or nonsmoking control subjects. Participants were classified as smokers (ever-smokers or current smokers) or nonsmokers (former or never-smokers), and as carrying normal CYP2A6 genes or one or more variant alleles. Information regarding cigarette consumption also was included. Effect sizes were calculated from each study and then aggregated into an overall effect size. This analysis failed to find any empirical evidence of a relationship between variant CYP2A6 alleles and smoking status (n=4,091) or cigarette consumption (n=1,537). Although these results suggest the CYP2A6 gene is not associated with smoking behavior, the use of broad smoking status classifications (e.g., ever- vs. never-smoking), which fail to account for the complex nature of gene expression (e.g., gene-gene interactions), may have obscured the relatively modest genetic influences that might have been present. What role, if any, the CYP2A6 gene plays in smoking behavior will be understood only if future research addresses these methodological concerns.
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页码:221 / 227
页数:7
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共 35 条
  • [1] Begg C.B., 1994, HDB RES SYNTHESIS, P399
  • [2] BENOWITZ NL, 1994, J PHARMACOL EXP THER, V268, P296
  • [3] Bierut LJ, 2000, AM J MED GENET, V90, P299, DOI 10.1002/(SICI)1096-8628(20000214)90:4<299::AID-AJMG7>3.0.CO
  • [4] 2-Y
  • [5] COMMINGS DE, 1996, PHARMACOGENETICS, V6, P73
  • [6] FERNANDEZSALGUERO P, 1995, AM J HUM GENET, V57, P651
  • [7] The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit
    Gu, DF
    Hinks, LJ
    Morton, NE
    Day, INM
    [J]. ANNALS OF HUMAN GENETICS, 2000, 64 : 383 - 390
  • [8] A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin
    Hadidi, H
    Zahlsen, K
    Idle, JR
    Cholerton, S
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 1997, 35 (09) : 903 - 907
  • [9] HEDGES LV, 1985, STAT METHODS META AN
  • [10] Lerman Caryn, 2002, Nicotine Tob Res, V4, P247, DOI 10.1080/14622200210141220