Development of topical nanoemulsions containing the isoflavone genistein

被引:50
|
作者
Silva, A. P. Cappra [1 ]
Nunes, B. R. [2 ]
de Oliveira, M. C. [2 ]
Koester, L. Scherer [1 ]
Mayorga, P. [1 ]
Bassani, V. Linck [1 ]
Teixeira, H. Ferreira [1 ]
机构
[1] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, BR-90610000 Porto Alegre, RS, Brazil
[2] Univ Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, Belo Horizonte, MG, Brazil
来源
PHARMAZIE | 2009年 / 64卷 / 01期
关键词
CHARGED SUBMICRON EMULSIONS; IN-VIVO; LC METHOD; SKIN; PREVENTION; DERMATOLOGY; FORMULATION; VALIDATION; ABSORPTION; QUERCETIN;
D O I
10.1691/ph.2008.8150
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
We have recently described the incorporation of genistein into topical nanoemulsions. This study describes the physicochemical properties and the genistein permeation profile from these nanoemulsions. Formulations composed of egg lecithin, medium chain triglycerides (MCT) or octyldodecanol (ODD) and water were prepared by spontaneous emulsification. Irrespective of the oil core employed (MCT or ODD), this procedure yielded monodisperse emulsions with mean droplet sizes in the range of 230-280 nm. The addition of genistein in the oil phase, before emulsification, did not alter the properties of nanoemulsions. The amount of genistein incorporated in both formulations was close to 100% (1 mg/mL). Solubility and DSC experiments suggested that egg-lecithin may play an important role on the incorporation of genistein in nanoemulsions. Genistein permeation from formulations was assessed using pig ear skin in Franz type diffusion cells. The overall results showed a slow permeation profile for genistein from both nanoemulsions. Such results open interesting perspectives for the topical administration of genistein.
引用
收藏
页码:32 / 35
页数:4
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