Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren A Pilot Study

被引：38

作者：

Barraza-Villarreal, Albino ^{[1
]}

Consuelo Escamilla-Nunez, Maria ^{[1
]}

Schilmann, Astrid ^{[1
]}

Hernandez-Cadena, Leticia ^{[1
]}

Li, Zheng ^{[2
]}

Romanoff, Lovisa ^{[2
]}

Sjoedin, Andreas ^{[2
]}

Estela Del Rio-Navarro, Blanca ^{[3
]}

Diaz-Sanchez, David ^{[4
]}

Diaz-Barriga, Fernando ^{[5
]}

Sly, Peter ^{[6
]}

Romieu, Isabelle ^{[1
,7
]}

机构：

[1] Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico

[2] Ctr Dis Control & Prevent, Atlanta, GA USA

[3] Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico

[4] US EPA, Res Triangle Pk, NC 27711 USA

[5] Univ Autonoma San Luis Potosi, San Luis Potosi, Mexico

[6] Univ Western Australia, Div Clin Sci, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia

[7] Int Agcy Res Canc, F-69372 Lyon 08, France

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2014年 / 56卷 / 04期

关键词：

CHILDREN; CITY; POLLUTANTS; POLLUTION; COHORT;

D O I：

10.1097/JOM.0000000000000111

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren. Methods: A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models. Results: A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (-11.2 mL, 95% CI: -22.2 to -0.02), forced vital capacity (-11.6 mL, 95% CI: -22.9 to -0.2), and pH of EBC (-0.035, 95% CI: -0.066 to -0.005). Conclusion: Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.

引用

页码：415 / 419

页数：5

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