Activation of cyclin D1 related kinase in human lung adenocarcinoma

被引：14

作者：

Igarashi, K

Masaki, T

Shiratori, Y

Rengifo, W

Nagata, T

Hara, K

Oka, T

Nakajima, J

Hisada, T

Hata, E

Omata, M

机构：

[1] Univ Tokyo, Fac Med, Dept Internal Med 2, Bunkyo Ku, Tokyo 113, Japan

[2] Univ Tokyo, Fac Med, Dept Pathol, Bunkyo Ku, Tokyo 113, Japan

[3] Univ Tokyo, Fac Med, Dept Cardiothorac Surg, Bunkyo Ku, Tokyo 113, Japan

[4] Tokyo Teishin Hosp, Div Resp Med, Chiyoda Ku, Tokyo 102, Japan

[5] Mitsui Mem Hosp, Dept Surg, Resp Ctr, Chiyoda Ku, Tokyo 101, Japan

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 81卷 / 04期

关键词：

cyclin D; cyclin-dependent kinase; kinase activity; Rb protein; lung cancer;

D O I：

10.1038/sj.bjc.6690752

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time that cyclin D1-related kinases are activated in NSCLC, especially in adenocarcinoma but not in squamous cell carcinoma. The results of this study strongly suggest that enhanced cyclin D1-related kinase activity could contribute to a progression of adenocarcinoma in NSCLC. (C)1999 Cancer Research Campaign.

引用

页码：705 / 711

页数：7

共 22 条

[1] CYCLIN D1 IS A NUCLEAR-PROTEIN REQUIRED FOR CELL-CYCLE PROGRESSION IN G(1) [J].