Comparison of developmental toxicity of seven perfluoroalkyl acids to zebrafish embryos

被引：85

作者：

Ulhaq, Mazhar ^{[1
]}

Carlsson, Gunnar ^{[1
]}

Orn, Stefan ^{[1
]}

Norrgren, Leif ^{[1
]}

机构：

[1] Swedish Univ Agr Sci, Dept Biomed Sci & Vet Publ Hlth, S-75007 Uppsala, Sweden

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2013年 / 36卷 / 02期

关键词：

Perfluoroalkyl acids; Zebrafish; Embryo; Toxicity; CARBON-CHAIN LENGTH; PERFLUORINATED COMPOUNDS; AQUATIC ORGANISMS; EXPOSURE; CHEMICALS; PFOS;

D O I：

10.1016/j.etap.2013.05.004

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The toxicity of individual perfluoroalkyl acids (PFAAs) has been suggested to be determined by the carbon chain length as well as the functional group attached. We tested seven different PFAAs including both sulfonic and carboxylic PFAAs with different chain length to evaluate the developmental toxicity in zebrafish embryos. Generally, the acute toxicity of PFAAs is relatively low to zebrafish embryos. The EC50 values ranged from 1.5 to 2200 mg/L. We observed a relationship between higher toxicity with longer carbon chain. In addition, we also observed a higher toxicity for sulfonic PFAAs than for carboxylic PFAAs. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：423 / 426

页数：4

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