Progressive multifocal leukoencephalopathy: new concepts

被引：9
作者：
Lima, Marco A. [1 ]
机构：
[1] Fiocruz MS, Inst Pesquisa Clin Evandro Chagas, BR-21040360 Rio De Janeiro, RJ, Brazil
来源：
ARQUIVOS DE NEURO-PSIQUIATRIA | 2013年 / 71卷 / 9B期
关键词：
leukoencephalopathy; natalizumab; JC virus; HIV-INFECTED PATIENTS; NATALIZUMAB; DISEASE; EPIDEMIOLOGY; PATHOGENESIS; SURVIVAL; THERAPY; PATIENT;
D O I：
10.1590/0004-282X20130154
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression. Originally, PML was observed in patients with advanced HIV infection, lymphoproliferative disorders and transplant recipients. However, the widespread use of HIV antiretroviral drugs and the new selective immunomodulatory and immunosuppressive medications, such as Rituximab and Natalizumab, has recently modified the epidemiology, clinical presentation and prognosis of PML. Herein, we discuss the new concepts on PML, emphasizing the recent modification in the epidemiology; the impact of new immunomodulatory treatments in the disease, PML-IRIS (Immune reconstitution inflammatory sindrome), new treatment strategies and other JCV related CNS diseases.
引用
收藏
页码：699 / 702
页数：4
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