Update Breast Cancer 2022 Part 4-Advanced-Stage Breast Cancer

被引：3

作者：

Aktas, Bahriye ^{[1
]}

Fehm, Tanja N. ^{[2
]}

Welslau, Manfred ^{[3
]}

Mueller, Volkmar ^{[4
]}

Lueftner, Diana ^{[5
,6
]}

Schuetz, Florian ^{[7
]}

Fasching, Peter A. ^{[8
]}

Janni, Wolfgang ^{[9
]}

Thomssen, Christoph ^{[10
]}

Witzel, Isabell ^{[4
]}

Belleville, Erik ^{[11
]}

Untch, Michael ^{[12
]}

Thill, Marc ^{[13
]}

Tesch, Hans ^{[14
]}

Ditsch, Nina ^{[15
]}

Lux, Michael P. ^{[16
]}

Banys-Paluchowski, Maggie ^{[17
]}

Kolberg-Liedtke, Cornelia ^{[18
]}

Hartkopf, Andreas D. ^{[9
]}

Woeckel, Achim ^{[19
]}

Kolberg, Hans-Christian ^{[20
]}

Stickeler, Elmar ^{[21
]}

Harbeck, Nadia ^{[22
,23
]}

Schneeweiss, Andreas ^{[24
,25
]}

机构：

[1] Univ Leipzig, Med Ctr, Dept Gynecol, Leipzig, Germany

[2] Univ Hosp Dusseldorf, Dept Gynecol & Obstet, Dusseldorf, Germany

[3] Onkol Aschaffenburg, Aschaffenburg, Germany

[4] Hamburg Eppendorf Univ Med Ctr, Dept Gynecol, Hamburg, Germany

[5] Immanuel Hosp Mark Schweiz, Buckow, Germany

[6] Med Univ Brandenburg Theodor Fontane, Buckow, Germany

[7] Diakonissen Stiftungs Krankenhaus Speyer, Gynakol & Geburtshilfe, Speyer, Germany

[8] Friedrich Alexander Univ Erlangen Nuremberg, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, Erlangen Univ Hosp, Erlangen, Germany

[9] Ulm Univ Hosp, Dept Gynecol & Obstet, Ulm, Germany

[10] Martin Luther Univ Halle Wittenberg, Dept Gynaecol, Halle, Saale, Germany

[11] ClinSol GmbH Co KG, Wurzburg, Germany

[12] Helios Klinikum Berlin Buch, Clin Gynecol & Obstet, Breast Canc Ctr, Gynecol Oncol Ctr, Berlin, Germany

[13] Agaples Markus Krankenhaus, Dept Gynecol & Gynecol Oncol, Frankfurt, Germany

[14] Bethanien Hosp, Frankfurt, Germany

[15] Univ Hosp Augsburg, Dept Gynecol & Obstet, Augsburg, Germany

[16] St Vincenz Krankenhaus GmbH, St Josefs Krankenhaus, Frauenklin St Louise Paderborn, Klin Gynakol & Geburtshilfe, Salzkotten, Germany

[17] Univ Hosp Schleswig Holstein, Dept Gynecol & Obstet, Campus Lubeck, Lubeck, Germany

[18] Univ Hosp Essen, Dept Gynecol & Obstet, Essen, Germany

[19] Univ Hosp Wurzburg, Dept Gynecol & Obstet, Wurzburg, Germany

[20] Marienhosp Bottrop, Dept Gynecol & Obstet, Bottrop, Germany

[21] RWTH Univ Hosp Aachen, Dept Gynecol & Obstet, Aachen, Germany

[22] LMU Univ Hosp, CCC Munich LMU, Munich, Germany

[23] LMU Univ Hosp, Breast Ctr, Dept Gynecol & Obstet, Munich, Germany

[24] Univ Heidelberg Hosp, Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[25] German Canc Res Ctr, Heidelberg, Germany

来源：

GEBURTSHILFE UND FRAUENHEILKUNDE | 2022年 / 82卷 / 09期

关键词：

advanced breast cancer; chemotherapy; endocrine therapy; antibody drug conjugates; FULVESTRANT PLUS CAPIVASERTIB; AROMATASE INHIBITOR; RIBOCICLIB; SURVIVAL; PLACEBO; POSTMENOPAUSAL; ABEMACICLIB; PALBOCICLIB; PROGRESSION; EXPRESSION;

D O I：

10.1055/a-1912-7362

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

For the treatment of patients with advanced HER2-negative hormone receptor-positive breast cancer, several substances have been introduced into practice in recent years. In addition, other drugs are under development. A number of studies have been published over the past year which have shown either an advantage for progression-free survival or for overall survival. This review summarizes the latest results, which have been published at current congresses or in specialist journals, and classifies them in the clinical treatment context. In particular, the importance of therapy with CDK4/6 inhibitors - trastuzumab deruxtecan, sacituzumab govitecan and capivasertib - is discussed. For trastuzumab deruxtecan, an overall survival benefit in HER2-negative breast cancer with low HER2 expression (HER2-low expression) was reported in the Destiny- Breast-04 study. Similarly, there was an overall survival benefit in the FAKTION study with capivasertib. The lack of overall survival benefit for palbociclib in the first line of therapy raises the question of clinical classification.

引用

页码：922 / 931

页数：10

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