Nickel (0)/dihydroimidazol-2-ylidene complex catalyzed coupling of aryl chlorides and amines

被引：203
作者：
Desmarets, C [1 ]
Schneider, R [1 ]
Fort, Y [1 ]
机构：
[1] Univ Nancy 1, UMR 7565, Fac Sci, F-54506 Vandoeuvre Les Nancy, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 09期
关键词：
D O I：
10.1021/jo016352l
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general and simple nickel-catalyzed coupling of aryl chlorides and amines is reported. The scope and limitations of the coupling process using Ni(0), 1,3-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene, and NaO-t-Bu as base were investigated. Secondary cyclic and acyclic amines and anilines provided the arylamine coupling products in good to excellent yields. Compared to palladium-catalyzed aminations, this procedure offers an alternative route to N-substituted anilines starting from readily available aryl chlorides.
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页码：3029 / 3036
页数：8
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