Transfection of dendritic cells with IL-21 mRNA gives rise to CD8+effector T cells with a higher proliferation rate and increased cytotoxic capacity

被引:0
|
作者
Turksma, Annelies W. [1 ]
Bontkes, Hetty J. [1 ]
Ruizendaal, Janneke J. [1 ]
van den Heuvel, Heleen [1 ]
Scholten, Kirsten B. J. [1 ]
Leemans, C. Rene [1 ]
Meijer, Chris J. L. M. [1 ]
Hooijberg, Erik [1 ]
机构
[1] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands
关键词
D O I
10.1158/1538-7445.AM2011-757
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
757
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Enhancement of proliferation and downregulation of TRAIL expression on CD8+ T cells by IL-21
    Melief, Cornelis J. M.
    Schoenberger, Stephen P.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (11) : 2990 - 2992
  • [2] IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype
    Casey, Kerry A.
    Mescher, Matthew F.
    JOURNAL OF IMMUNOLOGY, 2007, 178 (12): : 7640 - 7648
  • [3] LTx Patients with Increased Gastroesophageal Reflux Have Increased CD8+Effector T Cells in BAL
    Mertens, V.
    Blondeau, K.
    Vanaudenaerde, B.
    Vos, R.
    Verleden, S. E.
    Van Raemdonck, D. E.
    Verleden, G. M.
    Sifrim, D.
    Dupont, L. J.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2011, 30 (04): : S116 - S117
  • [4] LTx Patients With Increased Gastroesophageal Reflux Have Increased CD8+Effector T Cells in BAL
    Mertens, Veerle
    Blundeau, Kathleen
    Pauwels, Ans
    Farre, Ricard
    Vanaudenaerde, Bart M.
    Vos, Robin
    Van Raetndonck, Dirk E.
    Verleden, Gert M.
    Dupont, Lieven
    Sifrim, Daniel
    GASTROENTEROLOGY, 2011, 140 (05) : S255 - S255
  • [5] IL-15 and IL-21 Mediated Homeostatic Proliferation of Human CD8 Memory T cells
    Huy Nguyen
    Weng, Nan-ping
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [6] CD8+Effector Memory T Cells and IL-7Rα Function in Multiple Sclerosis
    Kreft, Karim
    Verbraak, Evert
    Wierenga-Wolf, Annet
    van Meurs, Marjan
    Laman, Jon
    Hintzen, Rogier
    CLINICAL IMMUNOLOGY, 2010, 135 : S115 - S115
  • [7] Differential Capacity of Human Skin Dendritic Cells to Polarize CD4+T Cells into IL-17, IL-21 and IL-22 Producing Cells
    Penel-Sotirakis, Karine
    Simonazzi, Elise
    Peguet-Navarro, Josette
    Rozieres, Aurore
    PLOS ONE, 2012, 7 (11):
  • [8] IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients
    Ricardo C. Ferreira
    Henry Z. Simons
    Whitney S. Thompson
    Antony J. Cutler
    Xaquin Castro Dopico
    Deborah J. Smyth
    Meghavi Mashar
    Helen Schuilenburg
    Neil M. Walker
    David B. Dunger
    Chris Wallace
    John A. Todd
    Linda S. Wicker
    Marcin L. Pekalski
    Diabetologia, 2015, 58 : 781 - 790
  • [9] IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients
    Ferreira, Ricardo C.
    Simons, Henry Z.
    Thompson, Whitney S.
    Cutler, Antony J.
    Dopico, Xaquin Castro
    Smyth, Deborah J.
    Mashar, Meghavi
    Schuilenburg, Helen
    Walker, Neil M.
    Dunger, David B.
    Wallace, Chris
    Todd, John A.
    Wicker, Linda S.
    Pekalski, Marcin L.
    DIABETOLOGIA, 2015, 58 (04) : 781 - 790
  • [10] Clonally expanded, thyrotoxic effector CD8+T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis
    Lechner, Melissa G.
    Zhou, Zikang
    Hoang, Aline T.
    Huang, Nicole
    Ortega, Jessica
    Scott, Lauren N.
    Chen, Ho -Chung
    Patel, Anushi Y.
    Yakhshi-Tafti, Rana
    Kim, Kristy
    Hugo, Willy
    Famini, Pouyan
    Drakaki, Alexandra
    Ribas, Antoni
    Angell, Trevor E.
    Su, Maureen A.
    SCIENCE TRANSLATIONAL MEDICINE, 2023, 15 (696)