Interactions of environment and genes in multiple sclerosis

被引:16
作者
Ebers, George [1 ]
机构
[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci Clin Neurol, Oxford OX3 9DU, England
关键词
Multiple sclerosis; Genes; Environment; MHC haplotypes; Interaction; Sunshine; BIRTH;
D O I
10.1016/j.jns.2013.08.018
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
MS susceptibility is comprised of both genetic and environmental factors and it has become increasingly clear that these interact. The major histocompatiblity complex is the major site of the interactions which determine MS risk. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:161 / 163
页数:3
相关论文
共 3 条
[1]   A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis [J].
Lincoln, MR ;
Montpetit, A ;
Cader, MZ ;
Saarela, J ;
Dyment, DA ;
Tiislar, M ;
Ferretti, V ;
Tienari, PJ ;
Sadovnick, AD ;
Peltonen, L ;
Ebers, GC ;
Hudson, TJ .
NATURE GENETICS, 2005, 37 (10) :1108-1112
[2]   HLA-DRB1 and month of birth in multiple sclerosis [J].
Ramagopalan, S. V. ;
Link, J. ;
Byrnes, J. K. ;
Dyment, D. A. ;
Giovannoni, G. ;
Hintzen, R. Q. ;
Sundqvist, E. ;
Kockum, I. ;
Smestad, C. ;
Lic, B. A. ;
Harbo, H. F. ;
Padyukov, L. ;
Alfredsson, L. ;
Olsson, T. ;
Sadovnick, A. D. ;
Hillert, J. ;
Ebers, G. C. .
NEUROLOGY, 2009, 73 (24) :2107-2111
[3]   Timing of birth and risk of multiple sclerosis: population based study. [J].
Willer, CJ ;
Dyment, DA ;
Sadovnick, AD ;
Rothwell, PM ;
Murray, TJ ;
Ebers, GC .
BMJ-BRITISH MEDICAL JOURNAL, 2005, 330 (7483) :120-123