Cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphism and susceptibility to non-Hodgkin's lymphoma

被引：69

作者：

Monne, M ^{[1
]}

Piras, G ^{[1
]}

Palmas, A ^{[1
]}

Arru, L ^{[1
]}

Murineddu, M ^{[1
]}

Latte, G ^{[1
]}

Noli, A ^{[1
]}

Gabbas, A ^{[1
]}

机构：

[1] San Francisco Gen Hosp, Div Hematol, Bone Marrow Transplant Unit, I-08100 Nuoro, Italy

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2004年 / 76卷 / 01期

关键词：

cytotoxic T-lymphocyte antigen-4; CTLA-4; gene polymorphism; genetic susceptibility; non-Hodgkin's lymphoma;

D O I：

10.1002/ajh.20045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The CTLA-4 molecule plays an important role in immune regulation by downregulating activation of T cells. Polymorphisms in the CTLA-4 gene have been shown to be associated to a number of autoimmune diseases including blood disorders. In this study, the intragenic polymorphisms of the CTLA-4 gene at position -318*C/T, +49*A/G, and the dinucleotide (AT)(n) repeat polymorphism in exon 3 were analyzed in patients with non-Hodgkin's lymphoma. Genotype and haplotype analysis showed that the exon 1+49*AA genotype was over-represented among patients with NHL (P = 0.002), whereas no difference was observed for the -318*C/T promoter and the (AT)(n) polymorphisms (P > 0.05). The data obtained indicate that the CTLA-4+49A/G polymorphism may have a role in genetic susceptibility to NHL. (C) 2004 Wiley-Liss, Inc.

引用

页码：14 / 18

页数：5

共 25 条

[1] A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele
Anjos, S
Nguyen, A
Ounissi-Benkalha, H
Tessier, MC
Polychronakos, C
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (48) : 46478 - 46486
[2] CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis
Braun, J
Donner, H
Siegmund, T
Walfish, PG
Usadel, KH
Badenhoop, K
[J]. TISSUE ANTIGENS, 1998, 51 (05): : 563 - 566
[3] Risk of non-Hodgkin lymphoma in celiac disease
Catassi, C
Fabiani, E
Corrao, G
Barbato, M
De Renzo, A
Carella, AM
Gabrielli, A
Leoni, P
Carroccio, A
Baldassarre, M
Bertolani, P
Caramaschi, P
Sozzi, M
Guariso, G
Volta, U
Corazza, GR
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (11): : 1413 - 1419
[4] EXPANSION OF T-CELLS EXPRESSING LOW CD4 OR CD8 LEVELS IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA - CORRELATION WITH DISEASE STATUS AND NEOPLASTIC PHENOTYPE
DIANZANI, U
OMEDE, P
MARMONT, F
DIFRANCO, D
FUSARO, A
BRAGARDO, M
REDOGLIA, V
GIARETTA, F
MAIRONE, L
BOCCADORO, M
RESEGOTTI, L
PILERI, A
[J]. BLOOD, 1994, 83 (08) : 2198 - 2205
[5] CTLA-4 gene polymorphism is associated with predisposition to coeliac disease
Djilali-Saiah, I
Schmitz, J
Harfouch-Hammoud, E
Mougenot, JF
Bach, JF
Caillat-Zucman, S
[J]. GUT, 1998, 43 (02) : 187 - 189
[6] CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
Donner, H
Rau, H
Walfish, PG
Braun, J
Siegmund, T
Finke, R
Herwig, J
Usadel, KH
Badenhoop, K
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (01) : 143 - 146
[7] Harbo HF, 1999, TISSUE ANTIGENS, V53, P106
[8] Technical note: Linkage disequilibrium and disease-associated CTLA4 gene polymorphisms
Holopainen, PM
Partanen, JA
[J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (05) : 2457 - 2458
[9] Dinucleotide repeat expansion in the CTLA-4 gene leads to T cell hyper-reactivity via the CD28 pathway in myasthenia gravis
Huang, DR
Giscombe, R
Zhou, YH
Pirskanen, R
Lefvert, AK
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2000, 105 (01) : 69 - 77
[10] CTLA4 is associated with susceptibility to multiple sclerosis
Kantarci, OH
Hebrink, DD
Achenbach, SJ
Atkinson, EJ
Waliszewska, A
Buckle, G
McMurray, CT
de Andrade, M
Hafler, DA
Weinshenker, BG
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2003, 134 (1-2) : 133 - 141

← 1 2 3 →