Stroke in patients with sickle cell disease

被引：0
|
作者：
Webb, Jennifer [1 ,2 ]
Kwiatkowski, Janet L. [1 ,2 ]
机构：
[1] Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
EXPERT REVIEW OF HEMATOLOGY | 2013年 / 6卷 / 03期
关键词：
cerebrovascular accident; chronic transfusion therapy; review; sickle cell anemia; stroke; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; CORD BLOOD TRANSPLANTATION; SILENT CEREBRAL INFARCTS; BONE-MARROW-TRANSPLANTATION; MAGNETIC-RESONANCE ANGIOGRAPHY; CENTRAL-NERVOUS-SYSTEM; MIXED HEMATOPOIETIC CHIMERISM; REDUCE IRON OVERLOAD; TRANSFUSION THERAPY; RECURRENT STROKE;
D O I：
10.1586/EHM.13.25
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Stroke is a significant cause of morbidity and mortality in children and adults with sickle cell disease. Great advances in the past couple of decades have enabled identification and treatment of children at risk of stroke, with a resultant dramatic reduction in stroke incidence in children. However, prevention and treatment of silent cerebral infarcts remain a challenge. This article reviews our current understanding of the epidemiology, risk factors and pathophysiology of small and large vessel disease with a focus on pediatric patients. The presentation and acute management of stroke in patients with sickle cell disease are discussed. Current recommendations for primary and secondary stroke prevention, as well as ongoing research studies and potential new therapies are reviewed.
引用
收藏
页码：301 / 316
页数：16
相关论文
共 50 条
  • [41] Stroke in sickle cell disease patients: transcranial Doppler and magnetic resonance imaging
    Bernaudin, Francoise
    Verlhac, Suzanne
    HEMATOLOGIE, 2008, 14 (01): : 25 - 35
  • [42] Enhancing Access to Stroke Neurology Care for Patients With Sickle Cell Disease.
    Lara-Angulo, Melissa
    Molokie, Robert
    Testai, Fernando D.
    STROKE, 2019, 50
  • [43] Stroke in sickle-cell patients in Yaounde
    Njamnshi, AK
    Mbong, EN
    Ongolo-Zogo, P
    Djientcheu, V
    Dongmo, L
    Mbanya, D
    Muna, W
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 238 : S424 - S424
  • [44] Leukocyte apoptosis and inflammation in iron-overloaded patients with sickle cell disease or β-thalassemia:: A mechanism for increased stroke and disease severity in sickle cell disease.
    Walter, Patrick B.
    Killilea, David W.
    Fung, Ellen B.
    Lui, Annie
    Madden, Jacqueline
    Porter, John
    Evans, Patricia
    Ames, Bruce N.
    Vichinsky, Elliott
    Harmatz, Paul
    BLOOD, 2006, 108 (11) : 363A - 363A
  • [45] Stroke may appear to be rare in Saudi-Arabian and Nigerian children with sickle cell disease, but not in Cameroonian sickle cell patients
    Njamnshi, AK
    Wonkam, A
    Djientcheu, VD
    Ongolo-Zogo, P
    Obama, MT
    Muna, WFT
    Sztajzel, R
    BRITISH JOURNAL OF HAEMATOLOGY, 2006, 133 (02) : 210 - 210
  • [46] Sickle Cell Disease and Stroke: Data from the Florida Stroke Registry
    Krementz, Nastajjia
    Wang, Kefeng
    Gutierrez, Carolina
    Asdaghi, Negar
    Sacco, Ralph
    Romano, Jose
    Rundek, Tatjana
    Campo-Bustillo, Iszet
    Campo-Bustillo, Iszet
    NEUROLOGY, 2022, 98 (18)
  • [47] Transcranial Doppler and prevention of stroke in sickle cell disease
    Verlhac, S.
    ARCHIVES DE PEDIATRIE, 2008, 15 (05): : 636 - 638
  • [48] A genetic component of stroke in sickle-cell disease
    Labie, Dominique
    HEMATOLOGIE, 2013, 19 (02): : 146 - 147
  • [49] Pediatric Sickle Cell Disease and Stroke: A Literature Review
    Parikh, Taral
    Goti, Ashish
    Yashi, Kanica
    Ravikumar, Naveen Prasad Gopalakrishnan
    Parmar, Narendrasinh
    Satodiya, Vimal
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (01)
  • [50] Use of aspirin for stroke prevention in sickle cell disease
    Nwosu, M. E.
    Panepinto, J.
    Amlie-Lefond, C.
    ANNALS OF NEUROLOGY, 2011, 70 : S125 - S126
12345