IL-18 and IL-1β Gene Polymorphisms: the Plausible Risk Factors for Chronic Hepatitis B

被引：11
作者：
Amirpour-Rostami, Sahar [1 ]
Arababadi, Mohammad Kazemi [2 ,3 ]
机构：
[1] Kerman Univ Med Sci, Pharmaceut Res Ctr, Inst Neuropharmacol, Kerman, Iran
[2] Rafsanjan Univ Med Sci, Immunol Infect Dis Res Ctr, Res Inst Basic Med Sci, Rafsanjan 7711681861, Iran
[3] Rafsanjan Univ Med Sci, Fac Paramed, Dept Lab Sci, Rafsanjan, Iran
来源：
VIRAL IMMUNOLOGY | 2019年 / 32卷 / 05期
关键词：
IL-18; IL-1; beta; inflammasome; chronic hepatitis B; hepatocellular carcinoma; cirrhosis; HEPATOCELLULAR-CARCINOMA; RECEPTOR ANTAGONIST; INTERLEUKIN-18; POLYMORPHISMS; PROMOTER REGION; ASSOCIATION; EXPRESSION; CYTOKINE; SUSCEPTIBILITY; PROGRESSION; MODULATION;
D O I：
10.1089/vim.2018.0155
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chronic inflammation is the main risk factor for induction of liver cirrhosis and also hepatocellular carcinoma in chronic hepatitis B (CHB) patients. Although our knowledge is growing regarding molecular mechanisms of immune responses against viruses, the main mechanisms that lead to the progression of chronic inflammation and then CHB are yet to be clarified. IL-18 and IL-1 beta are the members of the IL-1 family and produced in the cytoplasm of a wide range of immune and nonimmune cells and activated by inflammasome pathways. The cytokines play key roles in the pathologies of CHB. IL-18 and IL-1 beta productions are altered in CHB patients. It has been hypothesized that the polymorphisms within IL-18 and IL-1 beta genes may be the main reasons for the induction of chronic inflammation in CHB patients. This review article discusses the related investigations regarding the main correlation between the polymorphisms within IL-18 and IL-1 beta genes and CHB pathogenesis.
引用
收藏
页码：208 / 213
页数：6
相关论文
共 59 条
[1]   Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes [J].
Airoldi, I ;
Raffaghello, L ;
Cocco, C ;
Guglielmino, R ;
Roncella, S ;
Fedeli, F ;
Gambini, C ;
Pistoia, V .
CLINICAL CANCER RESEARCH, 2004, 10 (01) :144-154
[2]   Cytokine Levels and Histopathology in Chronic Hepatitis B and Chronic Hepatitis C [J].
Akcam, Fusun Zeynep ;
Tigli, Arzu ;
Kaya, Onur ;
Ciris, Metin ;
Vural, Huseyin .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2012, 32 (12) :570-574
[3]   Current information on the immunologic status of occult hepatitis B infection [J].
Arababadi, Mohammad Kazemi ;
Ahmadabadi, Behzad Nasiri ;
Kennedy, Derek .
TRANSFUSION, 2012, 52 (08) :1819-1826
[4]   Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis [J].
Arterbery, Adam S. ;
Yao, Jie ;
Ling, Andrew ;
Avitzur, Yaron ;
Martinez, Mercedes ;
Lobritto, Steven ;
Deng, Yanhong ;
Geliang, Gan ;
Mehta, Sameet ;
Wang, Guilin ;
Knight, James ;
Ekong, Udeme D. .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[5]  
AURON PE, 1994, EUR CYTOKINE NETW, V5, P573
[6]   Association between IL-18 polymorphisms, serum levels, and HBV-related hepatocellular carcinoma in a Chinese population: a retrospective case-control study [J].
Bao, Jingui ;
Lu, Yu ;
Deng, Yan ;
Rong, Chengzhi ;
Liu, Yanqiong ;
Huang, Xiuli ;
Song, Liuying ;
Li, Shan ;
Qin, Xue .
CANCER CELL INTERNATIONAL, 2015, 15
[7]   Combined Effects of Six Cytokine Gene Polymorphisms and SNP-SNP Interactions on Hepatocellular Carcinoma Risk in Southern Guangxi, China [J].
Bei, Chun-Hua ;
Bai, Hua ;
Yu, Hong-Ping ;
Yang, Yan ;
Liang, Qing-Qing ;
Deng, Ying-Ying ;
Tan, Sheng-Kui ;
Qiu, Xiao-Qiang .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (16) :6961-6967
[8]   Association of Interleukin-1 beta and Gene Polymorphisms with Liver Pathogenesis in Hepatitis B Virus Infection among Eastern Indian Population [J].
Biswas, Avik ;
Panigrahi, Rajesh ;
Pal, Manisha ;
De, Binay K. ;
Chakrabarti, Sekhar ;
Ghosh, Mrinmoy K. ;
Seth, Bikash C. Chandra ;
Roychowdhury, Susanta ;
Chakravarty, Runu .
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2013, 3 (04) :281-287
[9]  
Börekçi G, 2014, MIKROBIYOL BUL, V48, P271
[10]   The IL-18 Antagonist IL-18-Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment [J].
Carbotti, Grazia ;
Barisione, Gaia ;
Orengo, Anna Maria ;
Brizzolara, Antonella ;
Airoldi, Irma ;
Bagnoli, Marina ;
Pinciroli, Patrizia ;
Mezzanzanica, Delia ;
Centurioni, Maria Grazia ;
Fabbi, Marina ;
Ferrini, Silvano .
CLINICAL CANCER RESEARCH, 2013, 19 (17) :4611-4620
123456