In Vitro Activities of Amoxicillin-Clavulanate, Doxycycline, Ceftazidime, Imipenem, and Trimethoprim-Sulfamethoxazole against Biofilm of Brazilian Strains of Burkholderia pseudomallei

被引：10

作者：

Pinheiro Gomes Bandeira, Tereza de Jesus ^{[1
,3
,5
]}

Moreira, Camila Alencar ^{[3
]}

Nogueira Brilhante, Raimunda Samia ^{[1
,2
,3
]}

Collares Maia Castelo-Branco, Debora de Souza ^{[1
,3
]}

de Araujo Neto, Manoel Paiva ^{[1
,4
]}

Cordeiro, Rossana de Aguiar ^{[1
,2
,3
]}

Santos Rodrigues, Terezinha de Jesus ^{[1
,3
]}

Gadelha Rocha, Marcos Fabio ^{[1
,3
,4
]}

Costa Sidrim, Jose Julio ^{[1
,2
,3
]}

机构：

[1] Univ Fed Ceara, Specialized Med Mycol Ctr, Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Postgrad Program Med Sci, Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Postgrad Program Med Microbiol, Fortaleza, Ceara, Brazil

[4] Univ Estadual Ceara, Postgrad Program Vet Sci, Fortaleza, Ceara, Brazil

[5] LabPasteur DASA, Fortaleza, Ceara, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 11期

关键词：

STAPHYLOCOCCUS-AUREUS BIOFILMS; MELIOIDOSIS; QUANTIFICATION; ASSAY; SUSCEPTIBILITY; RESISTANCE; RESAZURIN;

D O I：

10.1128/AAC.00721-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study aimed at investigating the in vitro activities of amoxicillin-clavulanate, doxycycline, ceftazidime, imipenem, and trimethoprim-sulfamethoxazole against Burkholderia pseudomallei in planktonic and biofilm forms, through broth microdilution and resazurin-based viability staining, respectively. In planktonic growth, the strains were susceptible to the drugs, while in biofilm growth, significantly higher antimicrobial concentrations were required, especially for ceftazidime and imipenem, surpassing the resistance breakpoints. These results highlight the importance of the routine evaluation of biofilm antimicrobial susceptibility.

引用

页码：5771 / 5773

页数：3

共 6 条

[1] Variations in Ceftazidime and Amoxicillin-Clavulanate Susceptibilities within a Clonal Infection of Burkholderia pseudomallei
Sam, I-Ching
See, Kah Heng
Puthucheary, Savithri D.
JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (05) : 1556 - 1558
[2] In-vitro activity of β-lactams/trimethoprim-sulfamethoxazole combinations against different strains of Burkholderia pseudomallei
Mohamad, N., I
Harun, A.
Hasan, H.
Deris, Z. Z.
TROPICAL BIOMEDICINE, 2022, 39 (01) : 11 - 16
[3] Epidemiological cut-off value of clinical isolates of Burkholderia pseudomallei from Northern Queensland to meropenem, ceftazidime, trimethoprim/sulfamethoxazole and doxycycline by the microbroth dilution method
Maloney, Samuel
Engler, Cathy
Norton, Robert
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2017, 10 : 291 - 294
[4] In-Vitro Activity of Doxycycline and β-Lactam Combinations Against Different Strains of Burkholderia pseudomallei
Nurul Iman Mohamad
Azian Harun
Habsah Hasan
Zakuan Zainy Deris
Indian Journal of Microbiology, 2018, 58 : 244 - 247
[5] In-Vitro Activity of Doxycycline and β-Lactam Combinations Against Different Strains of Burkholderia pseudomallei
Mohamad, Nurul Iman
Harun, Azian
Hasan, Habsah
Deris, Zakuan Zainy
INDIAN JOURNAL OF MICROBIOLOGY, 2018, 58 (02) : 244 - 247
[6] In vitro activity of ceftazidime, ciprofloxacin, meropenem, minocycline, tobramycin and trimethoprim/sulfamethoxazole against planktonic and sessile Burkholderia cepacia complex bacteria
Peeters, Elke
Nelis, Hans J.
Coenye, Tom
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 64 (04) : 801 - 809

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