In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation

被引：79
作者：
Alghazwi, Mousa [1 ,2 ,3 ]
Smid, Scott [4 ]
Musgrave, Ian [4 ]
Zhang, Wei [1 ,2 ]
机构：
[1] Flinders Univ S Australia, Coll Med & Publ Hlth, CMBD, GPO Box 2100, Adelaide, SA 5001, Australia
[2] Flinders Univ S Australia, Coll Med & Publ Hlth, Med Biotechnol, GPO Box 2100, Adelaide, SA 5001, Australia
[3] Minist Higher Educ Saudi Arabia, King Faisal Hosp St, Riyadh 11153, Saudi Arabia
[4] Univ Adelaide, Fac Hlth Sci, Sch Med, Discipline Pharmacol, Adelaide, SA, Australia
来源：
NEUROCHEMISTRY INTERNATIONAL | 2019年 / 124卷
关键词：
Astaxanthin; Fucoxanthin; Neuroprotection; Amyloid beta; Alzheimer's disease; NERVE GROWTH-FACTOR; MARINE CAROTENOID FUCOXANTHIN; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; HUMAN HEALTH; PC12; CELLS; ALGAE; BIOAVAILABILITY; INHIBITORS; VIVO;
D O I：
10.1016/j.neuint.2019.01.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amyloid beta (A beta) can aggregate and form plaques, which are considered as one of the major hallmarks of Alzheimer's disease. This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against A beta(1-42)-mediated toxicity in pheochromocytoma (PC-12) neuronal cells using the MTT cell viability assay, anti-apoptotic, antioxidant and neurite outgrowth activities; as well as inhibition against A beta(1-42) fibrillization in the Thioflavin T (ThT) assay of fibril kinetics and via transmission electron microscopic (TEM) evaluation of fibril morphology. The results demonstrated that both astaxanthin and fucoxanthin exhibited multi-neuroprotective effects favouring fucoxanthin over astaxanthin supporting neuroprotective roles of marine-derived carotenoids as potential novel dementia prevention or therapeutic strategies.
引用
收藏
页码：215 / 224
页数：10
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