Capsaicin receptor antagonists: a promising new addition to the pain clinic

被引：23
作者：
Lambert, D. G. [1 ]
机构：
[1] Univ Leicester, Leicester Royal Infirm, Div Anaesthesia Crit Care & Pain Management, Dept Cardiovasc Sci,Pharmacol & Therapeut Grp, Leicester LE1 5WW, Leics, England
来源：
BRITISH JOURNAL OF ANAESTHESIA | 2009年 / 102卷 / 02期
关键词：
TRPV1; ANTAGONIST; EXPRESSION; SB-705498; HYPERALGESIA; POTENT; MODEL;
D O I：
10.1093/bja/aen354
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
引用
收藏
页码：153 / 155
页数：4
相关论文
共 18 条
[1]   Attenuation of experimental arthritis in TRPV1R knockout mice [J].
Barton, N. J. ;
McQueen, D. S. ;
Thomson, D. ;
Gauldie, S. D. ;
Wilson, A. W. ;
Salter, D. M. ;
Chessell, I. P. .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2006, 81 (02) :166-170
[2]   The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans [J].
Chizh, Boris A. ;
O'Donnell, Mary B. ;
Napolitano, Antonella ;
Wang, Jie ;
Brooke, Allison C. ;
Aylott, Mike C. ;
Bullman, Jonathan N. ;
Gray, Emily J. ;
Lai, Robert Y. ;
Williams, Pauline M. ;
Appleb, Jonathan M. .
PAIN, 2007, 132 (1-2) :132-141
[3]   Biochemical pharmacology of the vanilloid receptor TRPV1 - An update [J].
Cortright, DN ;
Szallasi, A .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (10) :1814-1819
[4]   Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis [J].
Fernihough, J ;
Gentry, C ;
Bevan, S ;
Winter, J .
NEUROSCIENCE LETTERS, 2005, 388 (02) :75-80
[5]   Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat- mediated activation of the receptor [J].
Gunthorpe, Martin J. ;
Hannan, Sara Luis ;
Smart, Darren ;
Jerman, Jeffrey C. ;
Arpino, Sandra ;
Smith, Graham D. ;
Brough, Stephen ;
Wright, Jim ;
Egerton, Julie ;
Lappin, Sarah C. ;
Holland, Vicky A. ;
Winborn, Kim ;
Thompson, Mervyn ;
Rami, Harshad K. ;
Randall, Andrew ;
Davis, John B. .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007, 321 (03) :1183-1192
[6]   Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia [J].
Kawamata, T. ;
Ji, W. ;
Yamamoto, J. ;
Niiyama, Y. ;
Furuse, S. ;
Namiki, A. .
NEUROSCIENCE, 2008, 154 (03) :1067-1076
[7]  
Morgan CR, 2005, J OROFAC PAIN, V19, P248
[8]   Bone cancer increases transient receptor potential vanilloid subfamily 1 expression within distinct subpopulations of dorsal root ganglion neurons [J].
Niiyama, Y. ;
Kawamata, T. ;
Yamamoto, J. ;
Omote, K. ;
Namiki, A. .
NEUROSCIENCE, 2007, 148 (02) :560-572
[9]   SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain [J].
Niiyama, Y. ;
Kawamata, T. ;
Yamamoto, J. ;
Furuse, S. ;
Namiki, A. .
BRITISH JOURNAL OF ANAESTHESIA, 2009, 102 (02) :251-258
[10]   Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development [J].
Rami, HK ;
Thompson, M ;
Stemp, G ;
Fell, S ;
Jerman, JC ;
Stevens, AJ ;
Smart, D ;
Sargent, B ;
Sanderson, D ;
Andrew, DR ;
Martin, JG ;
Davis, JB .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (12) :3287-3291
12