Podosomes in endothelial cell-microenvironment interactions

被引:7
|
作者
Alonso, Florian [1 ,2 ]
Spuul, Pirjo [3 ]
Genot, Elisabeth [1 ,2 ]
机构
[1] Univ Bordeaux, Bordeaux, France
[2] INSERM, U1045, Bordeaux, France
[3] Tallinn Univ Technol, Dept Chem & Biotechnol, Div Gene Technol, Tallinn, Estonia
关键词
actin cytoskeleton; basement membrane; endothelial cells; podosomes; vessel remodelling; EXTRACELLULAR-MATRIX; COLLAGEN-IV; CONTRACTILITY; ROSETTES; INSIGHTS; DEVICES; FORCE;
D O I
10.1097/MOH.0000000000000575
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review The discovery of podosomes in endothelial cells during the process of angiogenesis in vivo opens a new era in vascular biology. Podosomes are actin-based microdomains located at the plasma membrane that have been extensively described but in vitro and in other cells. This review focuses on podosomes in endothelial cells and aims to rise hypotheses about when and how these structures mediate cell--microenvironment interactions. Recent findings A wealth of new information regarding podosome organization and functioning has been collected in simple 2D models. Characterization of their modular architecture has unravelled their mechanics. However, context matters and podosome characteristics and functioning are shaped by the microenvironment. Although matrix degradation was seen as the typical function of podosomes, mechanosensing now appears equally prominent and involved in setting of the proteolytic machinery. Endothelial podosomes breach the basement membrane, and are thus, involved in vascular remodelling. Summary In endothelial cells, podosomes are involved in breaking up the basement membrane, giving the cells the opportunity to invade adjacent tissues and to engage in new cell-cell interactions. Such functions are particularly relevant to vascular biology and the exploration of podosomes in in vivo settings should bring clues to many unanswered questions.
引用
收藏
页码:197 / 205
页数:9
相关论文
共 50 条
  • [41] Leukocyte-endothelial cell interactions
    Wild, Martin K.
    Bixel, M. Gabriele
    FEBS JOURNAL, 2006, 273 (19) : 4375 - 4376
  • [42] ENDOTHELIAL-CELL INTERACTIONS WITH HEPARIN
    TOBELEM, G
    SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1989, 15 (02): : 197 - 199
  • [43] Adipocyte-Cancer Cell Interactions in the Bone Microenvironment
    Otley, Meredith O. C.
    Sinal, Christopher J.
    FRONTIERS IN ENDOCRINOLOGY, 2022, 13
  • [45] Activin A regulates cell interactions in the microenvironment of oral squamous cell carcinomas
    Coletta, Ricardo D.
    Bufalino, Andreia
    Sobral, Lays M.
    Rodrigues, Priscila C.
    Graner, Edgard
    Kowalski, Luis P.
    Salo, Tuula
    CANCER RESEARCH, 2015, 75 (01)
  • [46] CELL STROMA INTERACTIONS IN ENDOTHELIAL CELL-CULTURES
    WAXLER, B
    MEINEKE, C
    EISENSTEIN, R
    FEDERATION PROCEEDINGS, 1977, 36 (03) : 1068 - 1068
  • [47] TUMOR CELL-ENDOTHELIAL CELL INTERACTIONS IN THROMBOSIS
    Marchetti, M.
    Falanga, A.
    HAEMATOLOGICA, 2020, 105 : S12 - S12
  • [48] gamma/delta T cell endothelial cell interactions
    Jutila, MA
    VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996, 54 (1-4) : 105 - 110
  • [49] Acute myelogenous leukemia - microenvironment interactions: Role of endothelial cells and proteasome inhibition
    Liesveld, JL
    Rosell, KE
    Lu, CH
    Bechelli, J
    Phillips, G
    Lancet, JE
    Abboud, CN
    HEMATOLOGY, 2005, 10 (06) : 483 - 494
  • [50] Direct mapping of melanoma cell - endothelial cell interactions
    Varga, Bela
    Fazakas, Csilla
    Molnar, Judit
    Wilhelm, Imola
    Domokos, Reka A.
    Krizbai, Istvan A.
    Szegletes, Zsolt
    Varo, Gyorgy
    Vegh, Attila G.
    JOURNAL OF MOLECULAR RECOGNITION, 2017, 30 (06)