RNA-guided genome editing a la carte

被引：11
作者：
Horvath, Philippe [1 ]
Barrangou, Rodolphe [2 ]
机构：
[1] DuPont Nutr & Hlth, F-86220 Dange St Romain, France
[2] DuPont Nutr & Hlth, Madison, WI 53716 USA
来源：
CELL RESEARCH | 2013年 / 23卷 / 06期
关键词：
IMMUNE-SYSTEM; CRISPR/CAS; DNA; BACTERIA;
D O I：
10.1038/cr.2013.39
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage. © 2013 IBCB, SIBS, CAS All rights reserved.
引用
收藏
页码：733 / 734
页数：2
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