RNA-guided genome editing a la carte

被引：11

作者：

Horvath, Philippe ^{[1
]}

Barrangou, Rodolphe ^{[2
]}

机构：

[1] DuPont Nutr & Hlth, F-86220 Dange St Romain, France

[2] DuPont Nutr & Hlth, Madison, WI 53716 USA

来源：

CELL RESEARCH | 2013年 / 23卷 / 06期

关键词：

IMMUNE-SYSTEM; CRISPR/CAS; DNA; BACTERIA;

D O I：

10.1038/cr.2013.39

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage. © 2013 IBCB, SIBS, CAS All rights reserved.

引用

页码：733 / 734

页数：2

共 50 条

[21] RNA-guided genetic silencing systems in bacteria and archaea
Wiedenheft, Blake
Sternberg, Samuel H.
Doudna, Jennifer A.
NATURE, 2012, 482 (7385) : 331 - 338
[22] Genome-wide target specificity of CRISPR RNA-guided adenine base editors
Kim, Daesik
Kim, Da-eun
Lee, Gyeorae
Cho, Sung-Ik
Kim, Jin-Soo
NATURE BIOTECHNOLOGY, 2019, 37 (04) : 430 - +
[23] Structural basis for CRISPR RNA-guided DNA recognition by Cascade
Jore, Matthijs M.
Lundgren, Magnus
van Duijn, Esther
Bultema, Jelle B.
Westra, Edze R.
Waghmare, Sakharam P.
Wiedenheft, Blake
Pul, Uemit
Wurm, Reinhild
Wagner, Rolf
Beijer, Marieke R.
Barendregt, Arjan
Zhou, Kaihong
Snijders, Ambrosius P. L.
Dickman, Mark J.
Doudna, Jennifer A.
Boekema, Egbert J.
Heck, Albert J. R.
van der Oost, John
Brouns, Stan J. J.
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (05) : 529 - U141
[24] RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes
Humphrey, Sean E.
Kasinski, Andrea L.
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2015, 8
[25] RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
Hale, Caryn R.
Zhao, Peng
Olson, Sara
Duff, Michael O.
Graveley, Brenton R.
Wells, Lance
Terns, Rebecca M.
Terns, Michael P.
CELL, 2009, 139 (05) : 945 - 956
[26] Novel molecular requirements for CRISPR RNA-guided transposition
Walker, Matt W. G.
Klompe, Sanne E.
Zhang, Dennis J.
Sternberg, Samuel H.
NUCLEIC ACIDS RESEARCH, 2023, 51 (09) : 4519 - 4535
[27] DNA Targeting by a Minimal CRISPR RNA-Guided Cascade
Hochstrasser, Megan L.
Taylor, David W.
Kornfeld, Jack E.
Nogales, Eva
Doudna, Jennifer A.
MOLECULAR CELL, 2016, 63 (05) : 840 - 851
[28] The history and market impact of CRISPR RNA-guided nucleases
van Erp, Paul B. G.
Bloomer, Gary
Wilkinson, Royce
Wiedenheft, Blake
CURRENT OPINION IN VIROLOGY, 2015, 12 : 85 - 90
[29] RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection
Wang, Jianbin
Quake, Stephen R.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (36) : 13157 - 13162
[30] Programmable Biosensors Based on RNA-Guided CRISPR/Cas Endonuclease
Xiaolong Liu
Mubashir Hussain
Jianguo Dai
Yonghong Li
Lijun Zhang
Jian Yang
Zeeshan Ali
Nongyue He
Yongjun Tang
Biological Procedures Online, 24

← 1 2 3 4 5 →