Medial prefrontal cortex is involved in the discriminative stimulus effects of nicotine in rats

被引：8
作者：
Miyata, H
Ando, K
Yanagita, T
机构：
[1] Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, Tokyo 1058461, Japan
[2] Cent Inst Expt Anim, Miyamae Ku, Kawasaki, Kanagawa 2160001, Japan
[3] Jikei Univ, Sch Med, Dept Pharmacol 1, Minato Ku, Tokyo 1058461, Japan
来源：
PSYCHOPHARMACOLOGY | 1999年 / 145卷 / 02期
关键词：
nicotine; discriminative stimulus effect; medial prefrontal cortex; medial habenular nucleus;
D O I：
10.1007/s002130051054
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rationale: Central nicotinic receptors have been reported to be involved in the discriminative stimulus (DS) effects of nicotine. Objectives: The purpose of the present study was to investigate the role of the medial prefrontal cortex (mPFC) and the medial habenular nucleus (mHb) in the DS effects of nicotine. Methods: Substitution tests with nicotine administered into mPFC and mHb were conducted in rats trained to discriminate nicotine (0.5 mg/kg, SC) from saline in a two-lever, food reinforced, operant task. Results: Nicotine (40 mu g) administered into mPFC substituted for nicotine (0.5 mg/kg, SC), whereas nicotine administered into mHb did not. Conclusions: Together with our previous study indicating that the nucleus accumbens and the ventral tegmental area are partially involved in the DS effects of nicotine, the present study suggests that mPFC is primarily involved in the DS effects of nicotine.
引用
收藏
页码：234 / 236
页数：3
相关论文
共 50 条
  • [21] Pavlovian Extinction of the Discriminative Stimulus Effects of Nicotine and Ethanol in Rats Varies as a Function of Context
    Joseph R. Troisi
    The Psychological Record, 2011, 61 : 199 - 212
  • [22] PAVLOVIAN EXTINCTION OF THE DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE AND ETHANOL IN RATS VARIES AS A FUNCTION OF CONTEXT
    Troisi, Joseph R., II
    PSYCHOLOGICAL RECORD, 2011, 61 (02) : 199 - 212
  • [23] Restraint stress attenuates nicotine's locomotor stimulant but not discriminative stimulus effects in rats
    Harris, Andrew C.
    Mattson, Christina
    Shelley, David
    LeSage, Mark G.
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2014, 124 : 92 - 100
  • [24] The discriminative stimulus and reinforcing effects of nicotine in humans following nicotine pretreatment
    Perkins, KA
    Fonte, C
    Meeker, J
    White, W
    Wilson, A
    BEHAVIOURAL PHARMACOLOGY, 2001, 12 (01): : 35 - 44
  • [25] Preclinical and clinical research on the discriminative stimulus effects of nicotine
    Shoaib, Mohammed
    Perkins, Kenneth A.
    NEUROPHARMACOLOGY, 2020, 170
  • [26] THE DISCRIMINATIVE STIMULUS PROPERTIES OF AN ETHANOL-NICOTINE MIXTURE IN RATS
    GAUVIN, DV
    HOLLOWAY, FA
    JOURNAL OF PSYCHOPHARMACOLOGY, 1993, 7 (01) : 52 - 62
  • [27] Nicotine Causes Parallel Increases in Medial Prefrontal Cortex Gamma Oscillations and Visual Attention
    Simon, Nicholas
    Bueno, Lezio, Jr.
    Wegener, Meredyth
    Moghaddam, Bita
    NEUROPSYCHOPHARMACOLOGY, 2015, 40 : S437 - S437
  • [28] Effects of ketamine and pentobarbital on noradrenaline release from the medial prefrontal cortex in rats
    Takeshi Kubota
    Noriyuki Anzawa
    Kazuyoshi Hirota
    Hitoshi Yoshida
    Tetsuya Kushikata
    Akitomo Matsuki
    Canadian Journal of Anaesthesia, 1999, 46 : 388 - 392
  • [29] Activity in the Ventral Medial Prefrontal Cortex Is Necessary for the Therapeutic Effects of Extinction in Rats
    Fucich, Elizabeth A.
    Paredes, Denisse
    Saunders, Madeleine O.
    Morilak, David A.
    JOURNAL OF NEUROSCIENCE, 2018, 38 (06) : 1408 - 1417
  • [30] The Role of the Medial Prefrontal Cortex in the Play Fighting of Rats
    Bell, Heather C.
    McCaffrey, David R.
    Forgie, Margaret L.
    Kolb, Bryan
    Pellis, Sergio M.
    BEHAVIORAL NEUROSCIENCE, 2009, 123 (06) : 1158 - 1168
12345