Medial prefrontal cortex is involved in the discriminative stimulus effects of nicotine in rats

被引：8
|
作者：
Miyata, H
Ando, K
Yanagita, T
机构：
[1] Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, Tokyo 1058461, Japan
[2] Cent Inst Expt Anim, Miyamae Ku, Kawasaki, Kanagawa 2160001, Japan
[3] Jikei Univ, Sch Med, Dept Pharmacol 1, Minato Ku, Tokyo 1058461, Japan
来源：
PSYCHOPHARMACOLOGY | 1999年 / 145卷 / 02期
关键词：
nicotine; discriminative stimulus effect; medial prefrontal cortex; medial habenular nucleus;
D O I：
10.1007/s002130051054
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rationale: Central nicotinic receptors have been reported to be involved in the discriminative stimulus (DS) effects of nicotine. Objectives: The purpose of the present study was to investigate the role of the medial prefrontal cortex (mPFC) and the medial habenular nucleus (mHb) in the DS effects of nicotine. Methods: Substitution tests with nicotine administered into mPFC and mHb were conducted in rats trained to discriminate nicotine (0.5 mg/kg, SC) from saline in a two-lever, food reinforced, operant task. Results: Nicotine (40 mu g) administered into mPFC substituted for nicotine (0.5 mg/kg, SC), whereas nicotine administered into mHb did not. Conclusions: Together with our previous study indicating that the nucleus accumbens and the ventral tegmental area are partially involved in the DS effects of nicotine, the present study suggests that mPFC is primarily involved in the DS effects of nicotine.
引用
收藏
页码：234 / 236
页数：3
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