Medial prefrontal cortex is involved in the discriminative stimulus effects of nicotine in rats

被引：8
|
作者：
Miyata, H
Ando, K
Yanagita, T
机构：
[1] Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, Tokyo 1058461, Japan
[2] Cent Inst Expt Anim, Miyamae Ku, Kawasaki, Kanagawa 2160001, Japan
[3] Jikei Univ, Sch Med, Dept Pharmacol 1, Minato Ku, Tokyo 1058461, Japan
来源：
PSYCHOPHARMACOLOGY | 1999年 / 145卷 / 02期
关键词：
nicotine; discriminative stimulus effect; medial prefrontal cortex; medial habenular nucleus;
D O I：
10.1007/s002130051054
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rationale: Central nicotinic receptors have been reported to be involved in the discriminative stimulus (DS) effects of nicotine. Objectives: The purpose of the present study was to investigate the role of the medial prefrontal cortex (mPFC) and the medial habenular nucleus (mHb) in the DS effects of nicotine. Methods: Substitution tests with nicotine administered into mPFC and mHb were conducted in rats trained to discriminate nicotine (0.5 mg/kg, SC) from saline in a two-lever, food reinforced, operant task. Results: Nicotine (40 mu g) administered into mPFC substituted for nicotine (0.5 mg/kg, SC), whereas nicotine administered into mHb did not. Conclusions: Together with our previous study indicating that the nucleus accumbens and the ventral tegmental area are partially involved in the DS effects of nicotine, the present study suggests that mPFC is primarily involved in the DS effects of nicotine.
引用
收藏
页码：234 / 236
页数：3
相关论文
共 50 条
  • [1] Medial prefrontal cortex is involved in the discriminative stimulus effects of nicotine in rats
    H. Miyata
    K. Ando
    T. Yanagita
    Psychopharmacology, 1999, 145 : 234 - 236
  • [2] DISCRIMINATIVE STIMULUS EFFECTS OF THE NICOTINE ANTAGONIST MECAMYLAMINE IN RATS
    GARCHA, HS
    STOLERMAN, IP
    JOURNAL OF PSYCHOPHARMACOLOGY, 1993, 7 (01) : 43 - 51
  • [3] EFFECTS OF ACUTE NICOTINE AND ETHANOL ON MEDIAL PREFRONTAL CORTEX SELF-STIMULATION IN RATS
    ARREGUIAGUIRRE, A
    CLAROIZAGUIRRE, F
    GONIGARRIDO, MJ
    ZARATEOLEAGA, JA
    MORGADOBERNAL, I
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (01) : 15 - 20
  • [4] Ethanol does not affect discriminative stimulus effects of nicotine in rats
    Le Foll, B
    Goldberg, SR
    NEUROPSYCHOPHARMACOLOGY, 2005, 30 : S149 - S150
  • [5] Caffeine potentiates the discriminative-stimulus effects of nicotine in rats
    Maciej Gasior
    Maria Jaszyna
    Patrik Munzar
    Jeffrey M. Witkin
    Steven R. Goldberg
    Psychopharmacology, 2002, 162 : 385 - 395
  • [6] NICOTINE DOES NOT INTERACT WITH THE DISCRIMINATIVE STIMULUS EFFECTS OF CLOZAPINE IN RATS
    VILLANUEVA, HF
    AREZO, S
    ROSECRANS, JA
    DRUG DEVELOPMENT RESEARCH, 1992, 26 (02) : 195 - 202
  • [7] Brain regions mediating the discriminative stimulus effects of nicotine in rats
    Miyata, H
    Ando, K
    Yanagita, T
    CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE II: COCAINE, SUBSTITUTED AMPHETAMINES, GHB, AND OPIATES, 2002, 965 : 354 - 363
  • [8] Peripheral and central mechanisms involved in the discriminative stimulus effects of nicotine in monkeys
    Blaylock, Brandi L.
    Nader, Susan H.
    Nader, Michael A.
    FASEB JOURNAL, 2011, 25
  • [9] Brain sites mediating the discriminative stimulus effects of nicotine in rats
    Shoaib, M
    Stolerman, IP
    BEHAVIOURAL BRAIN RESEARCH, 1996, 78 (02) : 183 - 188
  • [10] Nicotine-like discriminative stimulus effects of bupropion in rats
    Wiley, JL
    LaVecchia, KL
    Martin, BR
    Damaj, MI
    EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2002, 10 (02) : 129 - 135
12345