Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis:: Identification of a novel mutation in inhA

被引：40

作者：

Leung, ETY ^{[1
]}

Ho, PL ^{[1
]}

Yuen, KY ^{[1
]}

Woo, WL ^{[1
]}

Lam, TH ^{[1
]}

Kao, RY ^{[1
]}

Seto, WH ^{[1
]}

Yam, WC ^{[1
]}

机构：

[1] Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 03期

关键词：

D O I：

10.1128/AAC.50.3.1075-1078.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.

引用

页码：1075 / 1078

页数：4

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