Deriving dopaminergic neurons for clinical use. A practical approach

被引：38

作者：

Gonzalez, Rodolfo ^{[1
]}

Garitaonandia, Ibon ^{[1
]}

Abramihina, Tatiana ^{[1
]}

Wambua, Gerald K. ^{[1
]}

Ostrowska, Alina ^{[1
]}

Brock, Mathew ^{[2
]}

Noskov, Alexander ^{[1
]}

Boscolo, Francesca S. ^{[3
,4
]}

Craw, John S. ^{[1
]}

Laurent, Louise C. ^{[4
]}

Snyder, Evan Y. ^{[5
]}

Semechkin, Ruslan A. ^{[1
]}

机构：

[1] Int Stem Cell Corp, Carlsbad, CA 92008 USA

[2] Axion Biosyst, Atlanta, GA 30332 USA

[3] Scripps Res Inst, Dept Physiol Chem, Ctr Regenerat Med, La Jolla, CA 92037 USA

[4] Univ Calif San Diego, Dept Reprod Med, San Diego, CA 92035 USA

[5] Sanford Burnham Med Res Inst, Stem Cell & Regenerat Program, La Jolla, CA 92037 USA

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

关键词：

PLURIPOTENT STEM-CELLS; DIFFERENTIATION;

D O I：

10.1038/srep01463

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.

引用

页数：5

共 3 条

[1] A Comprehensive Analysis of Protocols for Deriving Dopaminergic Neurons from Human Pluripotent Stem Cells
Marton, Rebecca M.
Ioannidis, John P. A.
STEM CELLS TRANSLATIONAL MEDICINE, 2019, 8 (04) : 366 - 374
[2] Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease
Wang, Yu-Kai
Zhu, Wan-Wan
Wu, Meng-Hua
Wu, Yi-Hui
Liu, Zheng-Xin
Liang, Ling-Min
Sheng, Chao
Hao, Jie
Wang, Liu
Li, Wei
Zhou, Qi
Hu, Bao-Yang
STEM CELL REPORTS, 2018, 11 (01): : 171 - 182
[3] Use of radiomics based on 18F-FDG PET/CT and machine learning methods to aid clinical decision-making in the classification of solitary pulmonary lesions: an innovative approach
Zhou, Yi
Ma, Xue-lei
Zhang, Ting
Wang, Jian
Zhang, Tao
Tian, Rong
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2021, 48 (09) : 2904 - 2913

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