XPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear

被引：0
作者：
Yilmaz, E. [1 ]
Celik, O. [1 ]
Celik, E. [1 ]
Turkcuoglu, I. [1 ]
Simsek, Y. [1 ]
Karaer, A. [1 ]
Otlu, B. [2 ]
Gulbay, G. [3 ]
Yesilada, E. [3 ]
机构：
[1] Inonu Univ, Dept Obstet & Gynecol, Fac Med, Turgut Ozal Med Ctr, Malatya, Turkey
[2] Inonu Univ, Dept Microbiol, Fac Med, Turgut Ozal Med Ctr, Malatya, Turkey
[3] Inonu Univ, Dept Genet, Fac Med, Turgut Ozal Med Ctr, Malatya, Turkey
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2012年 / 16卷 / 12期
关键词：
Cervical intraepithelial neoplasia; Polymorphism; Cervix; DNA repair; NORTH INDIAN POPULATION; CANCER; RISK; CARCINOMA; WOMEN; VARIANTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
AIM: The purpose of the present study was to identify the role of abnormalities in DNA repair pathways by measuring the XPD and XRCC1 gene polymorphisms. MATERIALS AND METHODS: Thirty-five patients with abnormal cervical cytology (study group) and 10 women with normal cytology (control group) were included in the study. The polymorphisms of XRCC1 Arg194Trp, XRCC1 Arg399Gln and XPD Lys751Gln genes were investigated from the blood samples. RESULTS: There was no statistically significant difference in allele frequencies of XPD gene among the groups (p = 0.097), while XRCC1R399Q gene polymorphism was strikingly more frequent in the study group than that of control cases (p = 0.029). The prevalence of XRCC1R194W gene polymorphism on the other hand, was similar between the groups (p = 0.579). CONCLUSIONS: Patients with abnormal and normal cervical cytology have similar XPD gene polymorphism. However, the frequency of gene polymorphism in XRCC1 Arg 399 Gln codon was significantly higher in abnormal cervical cytology group.
引用
收藏
页码：1713 / 1718
页数：6
相关论文
共 50 条
  • [21] Polymorphism of DNA Repair Gene xrcc1 and Lung Cancer Risk
    Wang, Hong
    Liu, Zhandi
    [J]. CELL BIOCHEMISTRY AND BIOPHYSICS, 2014, 70 (03) : 1881 - 1886
  • [22] Study on the DNA Repair Gene XRCC1 and XRCC3 Polymorphism in Prediction and Prognosis of Hepatocellular Carcinoma Risk
    Han, Xuechang
    Xing, Qunzhi
    Li, Yu
    Sun, Junjun
    Ji, Huihui
    Pan Huazheng
    Jun, Liang
    [J]. HEPATO-GASTROENTEROLOGY, 2012, 59 (119) : 2285 - 2289
  • [23] MRI-based radiogenomics analysis for predicting prognosis and XRCC1 gene polymorphism in pancreatic ductal adenocarcinoma
    Goktas, Muhammet
    Karabulut, Derya
    Unlue, Ayhan
    Achmet, Gkioulsoum
    Tuncbilek, Nermin
    [J]. CLINICAL & TRANSLATIONAL ONCOLOGY, 2024, : 2517 - 2526
  • [24] A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer
    Stoehlmacher, J
    Ghaderi, V
    Iqbal, S
    Groshen, S
    Tsao-Wei, D
    Park, D
    Lenz, HJ
    [J]. ANTICANCER RESEARCH, 2001, 21 (4B) : 3075 - 3079
  • [25] Polymorphism of the XRCC1 Gene Is Associated with Susceptibility and Short-Term Recovery of Ischemic Stroke
    He, Wei
    Huang, Peng
    Liu, Dinghua
    Zhong, Lingling
    Yu, Rongbin
    Li, Jianan
    [J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2016, 13 (10)
  • [26] Evaluation of DNA Repair Gene XRCC1 Polymorphism in Prediction and Prognosis of Hepatocellular Carcinoma Risk
    Li, Qiu-wen
    Lu, Can-rong
    Ye, Ming
    Xiao, Wen-hua
    Liang, Jun
    [J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (01) : 191 - 194
  • [27] Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus
    Gulnaz, Asma
    Sayyed, Ali H.
    Amin, Farah
    Khan, Abrar ul Haq
    Aslam, Muhammad A.
    Shaikh, Rehan S.
    Ali, Muhammad
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2013, 25 (02) : 166 - 179
  • [28] Polymorphism of DNA repair genes OGG1, XRCC1, XPD and ERCC6 in bladder cancer in Belarus
    Ramaniuk, Volha P.
    Nikitchenko, Nataliya V.
    Savina, Nataliya V.
    Kuzhir, Tatyana D.
    Rolevich, Alexander I.
    Krasny, Sergei A.
    Sushinsky, Vadim E.
    Goncharova, Roza I.
    [J]. BIOMARKERS, 2014, 19 (06) : 509 - 516
  • [29] Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome
    Joshi, Dolly
    Korgaonkar, Seema
    Shanmukhaiah, Chandrakala
    Vundinti, Babu Rao
    [J]. ANNALS OF HEMATOLOGY, 2016, 95 (01) : 79 - 85
  • [30] Association of XRCC1 and XPD functional gene variants with nicotine dependence and/or schizophrenia: a case-control study and in silico analysis
    Pehlivan, S.
    Aydin, N.
    Nursal, A. F.
    Uysal, M. A.
    Pehlivan, M.
    Tekcan, A.
    Yavuz, F. K.
    Sever, U.
    Yavuzlar, H.
    Kurnaz, S.
    Uysal, S.
    Aydin, P. C.
    [J]. PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, 2019, 29 (01) : 21 - 27
12345