Detection and molecular analysis of circulating tumor cells for early diagnosis of pancreatic cancer

被引：19
|
作者：
Ren, Chuanli [1 ,2 ]
Chen, Hui [1 ,2 ,3 ]
Han, Chongxu [1 ,2 ]
Jin, Guangfu [4 ]
Wang, Daxin [1 ,2 ]
Wang, Daorong [2 ,5 ]
Tang, Dong [2 ,5 ]
机构：
[1] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Med Lab, Yangzhou 225001, Peoples R China
[2] Yangzhou Univ, Clin Med Coll, Yangzhou 225001, Peoples R China
[3] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Geriatr Med, Yangzhou 225001, Peoples R China
[4] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 210029, Jiangsu, Peoples R China
[5] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Gastrointestinal Surg, Yangzhou 225001, Peoples R China
来源：
MEDICAL HYPOTHESES | 2013年 / 80卷 / 06期
关键词：
EPITHELIAL-CELLS; CARCINOMA; DISSEMINATION; PROGRESSION; METASTASES; MANAGEMENT; PATIENT;
D O I：
10.1016/j.mehy.2013.03.027
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Circulating tumor cells (CTCs) have the potential to provide a surrogate for "real-time biopsy" of tumor biological activity. Enumeration and molecular characterization of CFCs in pancreatic cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy biomarkers. CTCs can disseminate into peripheral blood in the preinvasive and early stages of pancreatic cancer. In view of these facts, we propose that identification and molecular analysis of the malignant characteristics of CTCs may serve as a "liquid biopsy" in pancreatic cancer for early diagnosis. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：833 / 836
页数：4
相关论文
共 50 条
  • [41] Circulating Tumor Cells Enumeration from the Portal Vein for Risk Stratification in Early Pancreatic Cancer Patients
    Padillo-Ruiz, Javier
    Suarez, Gonzalo
    Pereira, Sheila
    Calero-Castro, Francisco Jose
    Tinoco, Jose
    Marin, Luis
    Bernal, Carmen
    Cepeda-Franco, Carmen
    Alamo, Jose Maria
    Almoguera, Francisco
    Macher, Hada C.
    Villanueva, Paula
    Garcia-Fernandez, Francisco Jose
    Gallego, Inmaculada
    Romero, Manuel
    Gomez-Bravo, Miguel Angel
    Denninghoff, Valeria
    Serrano, Maria Jose
    CANCERS, 2021, 13 (24)
  • [42] Analysis of Circulating Tumor Cells in Breast Cancer
    Eroglu, Zeynep
    Fielder, Odicie
    Somlo, George
    JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2013, 11 (08): : 977 - 985
  • [43] Circulating Tumor Cells: A New Window for Diagnosis and Evaluation of Cancer
    Liu, Meihui
    Tang, Min
    Li, Ming
    Gao, Feng
    Shi, Can
    Hou, Jing
    Zeng, Wenbin
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2016, 16 (12) : 1529 - 1540
  • [44] Accurate Screening for Early-Stage Breast Cancer by Detection and Profiling of Circulating Tumor Cells
    Crook, Timothy
    Leonard, Robert
    Mokbel, Kefah
    Thompson, Alastair
    Michell, Michael
    Page, Raymond
    Vaid, Ashok
    Mehrotra, Ravi
    Ranade, Anantbhushan
    Limaye, Sewanti
    Patil, Darshana
    Akolkar, Dadasaheb
    Datta, Vineet
    Fulmali, Pradip
    Apurwa, Sachin
    Schuster, Stefan
    Srinivasan, Ajay
    Datar, Rajan
    CANCERS, 2022, 14 (14)
  • [45] A Comparison of Three Methods for the Detection of Circulating Tumor Cells in Patients with Early and Metastatic Breast Cancer
    Politaki, Eleni
    Agelaki, Sofia
    Apostolaki, Stella
    Hatzidaki, Dora
    Strati, Areti
    Koinis, Filippos
    Perraki, Maria
    Saloustrou, Georgia
    Stoupis, Giannis
    Kallergi, Galatea
    Spiliotaki, Maria
    Skaltsi, Tereza
    Lianidou, Evi
    Georgoulias, Vassilis
    Mavroudis, Dimitrios
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 44 (02) : 594 - 606
  • [46] Clinical impact of circulating tumor cells and therapy response in pancreatic cancer
    Okubo, K.
    Uenosono, Y.
    Arigami, T.
    Mataki, Y.
    Matsushita, D.
    Yanagita, S.
    Kurahara, H.
    Sakoda, M.
    Kijima, Y.
    Maemura, K.
    Natsugoe, S.
    EJSO, 2017, 43 (06): : 1050 - 1055
  • [47] Detection and Prognostic Significance of Circulating Tumor Cells in Patients With Metastatic Thyroid Cancer
    Xu, Jian Yu
    Handy, Beverly
    Michaelis, Christina L.
    Waguespack, Steven G.
    Hu, Mimi I.
    Busaidy, Naifa
    Jimenez, Camilo
    Cabanillas, Maria E.
    Fritsche, Herbert A., Jr.
    Cote, Gilbert J.
    Sherman, Steven I.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (11) : 4461 - 4467
  • [48] Isolation of circulating tumor cells from pancreatic cancer by automated filtration
    Brychta, Nora
    Drosch, Michael
    Driemel, Christiane
    Fischer, Johannes C.
    Neves, Rui P.
    Esposito, Irene
    Knoefel, Wolfram
    Moehlendick, Birte
    Hille, Claudia
    Stresemann, Antje
    Krahn, Thomas
    Kassack, Matthias U.
    Stoecklein, Nikolas H.
    von Ahsen, Oliver
    ONCOTARGET, 2017, 8 (49) : 86143 - 86156
  • [49] Circulating Tumor Cells and Transforming Growth Factor Beta in Resected Pancreatic Adenocarcinoma
    Vicente, Diego
    Lee, Andrew J.
    Hall, Carolyn S.
    Lucci, Anthony
    Lee, Jeffrey E.
    Kim, Michael P.
    Katz, Matthew H. G.
    Hurd, Mark W.
    Maitra, Anirban
    Rhim, Andrew D.
    Tzeng, Ching-Wei D.
    JOURNAL OF SURGICAL RESEARCH, 2019, 243 : 90 - 99
  • [50] Analysis of circulating tumor cells derived from advanced gastric cancer
    Toyoshima, Kosei
    Hayashi, Akira
    Kashiwagi, Masahide
    Hayashi, Naoko
    Iwatsuki, Masaaki
    Ishimoto, Takatsugu
    Baba, Yoshifumi
    Baba, Hideo
    Ohta, Yoshikazu
    INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (04) : 991 - 998
12345