Detection and molecular analysis of circulating tumor cells for early diagnosis of pancreatic cancer

被引：19
|
作者：
Ren, Chuanli [1 ,2 ]
Chen, Hui [1 ,2 ,3 ]
Han, Chongxu [1 ,2 ]
Jin, Guangfu [4 ]
Wang, Daxin [1 ,2 ]
Wang, Daorong [2 ,5 ]
Tang, Dong [2 ,5 ]
机构：
[1] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Med Lab, Yangzhou 225001, Peoples R China
[2] Yangzhou Univ, Clin Med Coll, Yangzhou 225001, Peoples R China
[3] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Geriatr Med, Yangzhou 225001, Peoples R China
[4] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 210029, Jiangsu, Peoples R China
[5] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Gastrointestinal Surg, Yangzhou 225001, Peoples R China
来源：
MEDICAL HYPOTHESES | 2013年 / 80卷 / 06期
关键词：
EPITHELIAL-CELLS; CARCINOMA; DISSEMINATION; PROGRESSION; METASTASES; MANAGEMENT; PATIENT;
D O I：
10.1016/j.mehy.2013.03.027
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Circulating tumor cells (CTCs) have the potential to provide a surrogate for "real-time biopsy" of tumor biological activity. Enumeration and molecular characterization of CFCs in pancreatic cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy biomarkers. CTCs can disseminate into peripheral blood in the preinvasive and early stages of pancreatic cancer. In view of these facts, we propose that identification and molecular analysis of the malignant characteristics of CTCs may serve as a "liquid biopsy" in pancreatic cancer for early diagnosis. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：833 / 836
页数：4
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