Detection and molecular analysis of circulating tumor cells for early diagnosis of pancreatic cancer

被引：19
|
作者：
Ren, Chuanli [1 ,2 ]
Chen, Hui [1 ,2 ,3 ]
Han, Chongxu [1 ,2 ]
Jin, Guangfu [4 ]
Wang, Daxin [1 ,2 ]
Wang, Daorong [2 ,5 ]
Tang, Dong [2 ,5 ]
机构：
[1] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Med Lab, Yangzhou 225001, Peoples R China
[2] Yangzhou Univ, Clin Med Coll, Yangzhou 225001, Peoples R China
[3] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Geriatr Med, Yangzhou 225001, Peoples R China
[4] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 210029, Jiangsu, Peoples R China
[5] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Gastrointestinal Surg, Yangzhou 225001, Peoples R China
来源：
MEDICAL HYPOTHESES | 2013年 / 80卷 / 06期
关键词：
EPITHELIAL-CELLS; CARCINOMA; DISSEMINATION; PROGRESSION; METASTASES; MANAGEMENT; PATIENT;
D O I：
10.1016/j.mehy.2013.03.027
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Circulating tumor cells (CTCs) have the potential to provide a surrogate for "real-time biopsy" of tumor biological activity. Enumeration and molecular characterization of CFCs in pancreatic cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy biomarkers. CTCs can disseminate into peripheral blood in the preinvasive and early stages of pancreatic cancer. In view of these facts, we propose that identification and molecular analysis of the malignant characteristics of CTCs may serve as a "liquid biopsy" in pancreatic cancer for early diagnosis. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：833 / 836
页数：4
相关论文
共 50 条
  • [1] Circulating tumor cells in the diagnosis and management of pancreatic cancer
    Cen, Putao
    Ni, Xiaoling
    Yang, Jingxuan
    Graham, David Y.
    Li, Min
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1826 (02): : 350 - 356
  • [2] Circulating Tumor Cells in Pancreatic Cancer Patients: Efficacy in Diagnosis and Value in Prognosis
    Xie, Zhi-Bo
    Yao, Lie
    Jin, Chen
    Fu, De-Liang
    DISCOVERY MEDICINE, 2016, 22 (120) : 121 - 128
  • [3] Prognostic Role of Circulating Tumor Cells in Patients with Pancreatic Cancer: a Meta-analysis
    Ma, Xue-Lei
    Li, Yan-Yan
    Zhang, Jing
    Huang, Jing-Wen
    Jia, Hong-Yuan
    Liu, Lei
    Li, Ping
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (15) : 6015 - 6020
  • [4] Improving pancreatic cancer diagnosis using circulating tumor cells: prospects for staging and single-cell analysis
    Court, Colin M.
    Ankeny, Jacob S.
    Hou, Shuang
    Tseng, Hsian-Rong
    Tomlinson, James S.
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2015, 15 (11) : 1491 - 1504
  • [5] Circulating Tumor Cells in Pancreatic Cancer: Current Perspectives
    Martini, Verena
    Timme-Bronsert, Sylvia
    Fichtner-Feigl, Stefan
    Hoeppner, Jens
    Kulemann, Birte
    CANCERS, 2019, 11 (11)
  • [6] Mesenchymal and stemness circulating tumor cells in early breast cancer diagnosis
    Barriere, Guislaine
    Riouallon, Alain
    Renaudie, Joel
    Tartary, Michel
    Rigaud, Michel
    BMC CANCER, 2012, 12
  • [7] Combined detection of aneuploid circulating tumor-derived endothelial cells and circulating tumor cells may improve diagnosis of early stage non-small-cell lung cancer
    Lei, Yuanyuan
    Sun, Nan
    Zhang, Guochao
    Liu, Chengming
    Lu, Zhiliang
    Huang, Jianbing
    Zhang, Chaoqi
    Zang, Ruochuan
    Che, Yun
    Mao, Shuangshuang
    Fang, Lingling
    Wang, Xinfeng
    Zheng, Sufei
    He, Jie
    CLINICAL AND TRANSLATIONAL MEDICINE, 2020, 10 (03):
  • [8] Multimarker Gene Analysis of Circulating Tumor Cells in Pancreatic Cancer Patients: A Feasibility Study
    de Albuquerque, Andreia
    Kubisch, Ilja
    Breier, Georg
    Stamminger, Gudrun
    Fersis, Nikos
    Eichler, Astrid
    Kaul, Sepp
    Stoelzel, Ulrich
    ONCOLOGY, 2012, 82 (01) : 3 - 10
  • [9] Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations
    Kulemann, Birte
    Roesch, Stephanie
    Seifert, Sindy
    Timme, Sylvia
    Bronsert, Peter
    Seifert, Gabriel
    Martini, Verena
    Kuvendjiska, Jasmina
    Glatz, Torben
    Hussung, Saskia
    Fritsch, Ralph
    Becker, Heiko
    Pitman, Martha B.
    Hoeppner, Jens
    SCIENTIFIC REPORTS, 2017, 7
  • [10] A combination of circulating tumor cells and CA199 improves the diagnosis of pancreatic cancer
    Chen, Junliang
    Wang, Huaitao
    Zhou, Lei
    Liu, Zhihao
    Tan, Xiaodong
    JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2022, 36 (05)
12345