Estrus-Cycle Regulation of Cortical Inhibition

被引:64
作者
Clemens, Ann M. [1 ]
Lenschow, Constanze [2 ]
Beed, Prateep [3 ,4 ,5 ,6 ,7 ]
Li, Lanxiang [8 ]
Sammons, Rosanna [3 ,4 ,5 ,6 ,7 ]
Naumann, Robert K. [8 ]
Wang, Hong [8 ]
Schmitz, Dietmar [3 ,4 ,5 ,6 ,7 ]
Brecht, Michael [1 ,3 ,4 ,5 ,6 ,7 ]
机构
[1] Humboldt Univ, Bernstein Ctr Computat Neurosci Berlin, Philippstr 13,Haus 6, D-10115 Berlin, Germany
[2] Champalimaud Ctr Unknown, Neurosci, Ave Brasilia, P-1400038 Lisbon, Portugal
[3] Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany
[4] Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany
[5] Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany
[6] Berlin Inst Hlth, Charitepl 1, D-10117 Berlin, Germany
[7] NeuroCure Cluster Excellence, Neurosci Res Ctr, Charitepl 1, D-10117 Berlin, Germany
[8] Chinese Acad Sci, Shenzhen Inst Adv Technol, Xueyuan Blvd, Shenzhen 518055, Peoples R China
关键词
NON-GENOMIC ACTIONS; IN-VIVO; PYRAMIDAL NEURONS; DYNAMIC BALANCE; ER-BETA; RAT; ESTROGEN; CORTEX; EXCITATION; 17-BETA-ESTRADIOL;
D O I
10.1016/j.cub.2019.01.045
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Female mammals experience cyclical changes in sexual receptivity known as the estrus cycle. Little is known about how estrus affects the cortex, although alterations in sensation, cognition and the cyclical occurrence of epilepsy suggest brain-wide processing changes. We performed in vivo juxtacellular and whole-cell recordings in somatosensory cortex of female rats and found that the estrus cycle potently altered cortical inhibition. Fast-spiking interneurons were strongly activated with social facial touch and varied their ongoing activity with the estrus cycle and estradiol in ovariectomized females, while regular-spiking excitatory neurons did not change. In situ hybridization for estrogen receptor beta (Esr2) showed co-localization with parvalbumin-positive (PV+) interneurons in deep cortical layers, mirroring the laminar distribution of our physiological findings. The fraction of neurons positive for estrogen receptor beta (Esr2) and PV co-localization (Esr2(+) PV+) in cortical layer V was increased in proestrus. In vivo and in vitro experiments confirmed that estrogen acts locally to increase fast-spiking interneuron excitability through an estrogen-receptorb-beta-dependent mechanism.
引用
收藏
页码:605 / +
页数:17
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