A fast-responsive two-photon fluorescent probe for in vivo imaging superoxide radical anion with a large stokes shift

被引：14

作者：

Xuan, Yunpeng ^{[1
]}

Qu, Jianbo ^{[2
]}

机构：

[1] Qingdao Univ, Affiliated Hosp, Med Coll, Dept Chest Surg, Qingdao 266071, Peoples R China

[2] Qi Lu Univ Technol, Shandong Acad Sci, Coll Leather Chem & Engn, Jinan 250353, Shandong, Peoples R China

来源：

RSC ADVANCES | 2018年 / 8卷 / 08期

关键词：

REACTIVE OXYGEN; HUMAN-DISEASE; ANTIOXIDANTS; GENERATION; CELLS; MACROPHAGES; MOUSE; VITRO;

D O I：

10.1039/c7ra11695k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and simple two-photon fluorescent probe NS-O for the detection of superoxide radical anion (O-2(center dot-)) with a large turn-on fluorescence signal is presented. The probe NS-O exhibited favorable properties including fast response, high selectivity, large stokes shift, low cytotoxicity and almost 100-fold fluorescence enhancement in solution. The two-photon probe could be applied to monitor endogenous superoxide radical anions in living cells and tissues. Notably, the two-photon fluorescent probe NS-O could be used to image superoxide radical anions in zebrafish.

引用

页码：4125 / 4129

页数：5

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