Association of ZNF184, IL1R2, LRRK2, ITPKB, and PARK16 with sporadic Parkinson's disease in Eastern China

被引：7

作者：

Gao, Ting ^{[1
]}

Zheng, Ran ^{[1
]}

Ruan, Yang ^{[1
]}

Fang, Yi ^{[1
]}

Jin, Chongyao ^{[1
]}

Cao, Jin ^{[1
]}

Song, Zhe ^{[1
]}

Tian, Jun ^{[1
]}

Pu, Jiali ^{[1
]}

Zhang, Baorong ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Coll Med, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2020年 / 735卷

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; ZNF184; IL1R2; LRRK2; ITPKB; PARK16; GENOME-WIDE ASSOCIATION; RISK LOCI; METAANALYSIS; IDENTIFICATION; VARIANTS;

D O I：

10.1016/j.neulet.2020.135261

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Genetic factors may play important roles in the pathogenesis of Parkinson's disease, and more than 40 loci involved in Parkinson's disease have been identified. Due to differing allele frequencies across origins, the associations of these loci and sporadic Parkinson's disease in the Eastern Chinese population are still unclear. Objective: The aim of this study was to investigate the relationship between 20 single nucleotide polymorphisms and Parkinson's disease in the Eastern Chinese population. Methods: A total of 441 Parkinson's disease patients and 384 healthy controls were recruited. The MassARRAY System was used to detect 20 single nucleotide polymorphisms. Odds ratios (OR) were calculated to assess the relationship between polymorphisms and Parkinson's disease susceptibility. Results: We found that ITPKB rs4653767 (OR [95 % confidential interval (CI)] = 0.524 [0.309 - 0.922], p = 0.023), ZNF184 rs9468199 (OR [95 % CI] = 0.530 [0.326 - 0.862], p = 0.010), ILIR2 rs34043159 (OR [95 % CI] = 0.794 [0.651 - 0.968], p = 0.022), LRRK2 rs76904798 (OR [95 % CI] = 0.397 [0.225 - 0.700], p = 0.001), and PARK16 rs11240572 (OR [95 % CI] = 0.715 [0.531 - 0.962], p = 0.027) were significantly associated with Parkinson's disease. Conclusions: LRRK2 rs76904798, ZNF184 rs9468199, PARK16 rs11240572, ITPKB rs4653767, and IL1R2 rs34043159 may associate with Parkinson's disease in the Eastern Han Chinese population.

引用

页数：6

共 22 条

[1] A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci [J].