Pediatric Inflammatory Multisystem Syndrome With Central Nervous System Involvement and Hypocomplementemia Following SARS-COV-2 Infection

被引：32

作者：

Regev, Tslil ^{[1
]}

Antebi, Maayan ^{[1
]}

Eytan, Danny ^{[2
,3
]}

Shachor-Meyouhas, Yael ^{[4
]}

Ilivitzki, Anat ^{[3
,5
]}

Aviel, Yonatan Butbul ^{[3
,6
,7
]}

Ben-Ari, Josef ^{[2
]}

机构：

[1] Rambam Hlth Care Campus, Ruth Rappaport Childrens Hosp, Haifa, Israel

[2] Rambam Hlth Care Campus, Pediat Crit Care Unit, Haifa, Israel

[3] The Technion, Fac Med, Haifa, Israel

[4] Rambam Hlth Care Campus, Pediat Infect Dis Unit, Haifa, Israel

[5] Rambam Hlth Care Campus, Pediat Radiol Unit, Haifa, Israel

[6] Rambam Hlth Care Campus, Dept Pediat B, Haifa, Israel

[7] Rambam Hlth Care Campus, Pediat Rheumatol Serv, Ruth Rappaport Childrens Hosp, Haifa, Israel

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2020年 / 39卷 / 08期

关键词：

D O I：

10.1097/INF.0000000000002804

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pediatric inflammatory multisystem syndromes associated with Severe Acute Respiratory Syndrome Coronavirus 2 are emerging in recent reports. We describe a patient with critical illness consistent with atypical Kawasaki disease with cardiac dysfunction and abdominal involvement presenting weeks after Severe Acute Respiratory Syndrome Coronavirus 2 infection. Our patient showed unique central nervous system involvement with small vessel vasculitis and profound hypocomplementemia, both not previously reported in case descriptions and may hint at possible disease mechanisms.

引用

页码：E206 / E207

页数：2

共 10 条

[1] Will Complement Inhibition Be the New Target in Treating COVID-19-Related Systemic Thrombosis? [J].

Campbell, Courtney M. ;

Kahwash, Rami .

CIRCULATION, 2020, 141 (22) :1739-1741

[2] Clinical profiles and diagnostic challenges in 1158 children with rare hepatobiliary disorders [J].

Dong, Yi ;

Wang, Jian ;

Zhu, Shishu ;

Zheng, Huanwei ;

Wang, Chunya ;

Zhao, Pan .

PEDIATRIC RESEARCH, 2021, 89 (01) :238-245

[3] Association between a novel human coronavirus and Kawasaki disease [J].

Esper, F ;

Shapiro, ED ;

Weibel, C ;

Ferguson, D ;

Landry, ML ;

Kahn, JS .

JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (04) :499-502

[4]

European Centre for Disease Prevention and Control (ECDC), 2020, PAED INFL MULT SYNDR

[5] Cerebral vasculitis in severe Kawasaki disease: early detection by magnetic resonance imaging and good outcome after intensive treatment [J].

Gitiaux, Cyril ;

Kossorotoff, Manoelle ;

Bergounioux, Jean ;

Adjadj, Elias ;

Lesage, Fabrice ;

Boddaert, Nathalie ;

Hully, Marie ;

Brugel, Dominique ;

Desguerre, Isabelle ;

Bader-Meunier, Brigitte .

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2012, 54 (12) :1160-1163

[6] Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding [J].

Lu, Roujian ;

Zhao, Xiang ;

Li, Juan ;

Niu, Peihua ;

Yang, Bo ;

Wu, Honglong ;

Wang, Wenling ;

Song, Hao ;

Huang, Baoying ;

Zhu, Na ;

Bi, Yuhai ;

Ma, Xuejun ;

Zhan, Faxian ;

Wang, Liang ;

Hu, Tao ;

Zhou, Hong ;

Hu, Zhenhong ;

Zhou, Weimin ;

Zhao, Li ;

Chen, Jing ;

Meng, Yao ;

Wang, Ji ;

Lin, Yang ;

Yuan, Jianying ;

Xie, Zhihao ;

Ma, Jinmin ;

Liu, William J. ;

Wang, Dayan ;

Xu, Wenbo ;

Holmes, Edward C. ;

Gao, George F. ;

Wu, Guizhen ;

Chen, Weijun ;

Shi, Weifeng ;

Tan, Wenjie .

LANCET, 2020, 395 (10224) :565-574

[7] Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases [J].

Magro, Cynthia ;

Mulvey, J. Justin ;

Berlin, David ;

Nuovo, Gerard ;

Salvatore, Steven ;

Harp, Joanna ;

Baxter-Stoltzfus, Amelia ;

Laurence, Jeffrey .

TRANSLATIONAL RESEARCH, 2020, 220 :1-13

[8] Children with Covid-19 in Pediatric Emergency Departments in Italy [J].

Parri, Niccolo ;

Lenge, Matteo ;

Buonsenso, Danilo .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (02) :187-190

[9]

Riphagen Shelley, 2020, Lancet, V395, P1607, DOI 10.1016/S0140-6736(20)31094-1

[10]

WHO, NOV COR CHIN

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