Current understanding of the interactions between metal ions and Apolipoprotein E in Alzheimer?s disease

被引：19

作者：

Zhang, Yanhui ^{[1
]}

Gao, Huiling ^{[2
]}

Zheng, Wei ^{[3
]}

Xu, He ^{[4
,5
]}

机构：

[1] China Med Univ, Dept Tissue Engn, Shenyang, Peoples R China

[2] Northeastern Univ, Inst Neurosci, Coll Life & Hlth Sci, Shenyang, Peoples R China

[3] China Med Univ, Dept Histol & Embryol, Shenyang, Peoples R China

[4] Shenzhen Univ, Sch Med, Dept Anat Histol & Embryol, Shenzhen, Peoples R China

[5] A7 Bldg, 1066 Xueyuan Rd, Shenzhen 518055, Peoples R China

来源：

NEUROBIOLOGY OF DISEASE | 2022年 / 172卷

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; Zinc; Copper; Iron; Apolipoprotein E (ApoE); AMYLOID PRECURSOR PROTEIN; TAU-MEDIATED NEURODEGENERATION; THROMBIN-CLEAVAGE FRAGMENT; A-BETA; MOUSE MODEL; APOE EPSILON-4; COGNITIVE IMPAIRMENT; IRON ACCUMULATION; OXIDATIVE STRESS; COPPER LEVELS;

D O I：

10.1016/j.nbd.2022.105824

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD), the most common type of dementia in the elderly, is a chronic and progressive neurodegenerative disorder with no effective disease-modifying treatments to date. Studies have shown that an imbalance in brain metal ions, such as zinc, copper, and iron, is closely related to the onset and progression of AD. Many efforts have been made to understand metal-related mechanisms and therapeutic strategies for AD. Emerging evidence suggests that interactions of brain metal ions and apolipoprotein E (ApoE), which is the strongest genetic risk factor for late-onset AD, may be one of the mechanisms for neurodegeneration. Here, we summarize the key points regarding how metal ions and ApoE contribute to the pathogenesis of AD. We further describe the interactions between metal ions and ApoE in the brain and propose that their interactions play an important role in neuropathological alterations and cognitive decline in AD.

引用

页数：12

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