Increased percentage of CD8+CD28- T cells correlates with clinical activity in primary Sjogren's syndrome

被引：8
作者：
Smolenska, Zaneta [2 ]
Pawlowska, Justyna [1 ]
Zdrojewski, Zbigniew [2 ]
Daca, Agnieszka [1 ]
Bryl, Ewa [1 ]
机构：
[1] Med Univ Gdansk, Dept Pathophysiol, PL-88210 Gdansk, Poland
[2] Med Univ Gdansk, Dept Internal Med Connect Tissue Dis & Geriatr, PL-88210 Gdansk, Poland
来源：
CELLULAR IMMUNOLOGY | 2012年 / 278卷 / 1-2期
关键词：
Sicca syndrome; Primary Sjogren's syndrome; T cell subpopulations; CD28; molecule; Costimulation signal; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; CLASSIFICATION CRITERIA; MULTIPLE-SCLEROSIS; IMMUNE-SYSTEM; CD28; CD8(+)CD28(-); AUTOIMMUNITY; LYMPHOCYTES; EXPRESSION;
D O I：
10.1016/j.cellimm.2012.08.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The role of CD28- T cell subpopulations in primary Sjogren's syndrome (pSS) has become controversial. Changes in the number of CD28- T cells have been demonstrated in autoimmune diseases in co-existence with Sjogren's syndrome. The study aimed to indicate differences in the number of CD4+CD28- and CD8+CD28- T cells in patients with sicca syndrome and suspected pSS. Thirty patients with sicca syndrome at baseline were studied and followed up for 5 months. After final diagnosis, comparison was made of the previously recorded lymphocyte subpopulations in patients with pSS and those in other defined subgroups. Notably high percentages of CD8+CD28- T cells were indicated in pSS patients, which correlated with the severity of the sicca symptoms and cutaneous and muscular systemic disease activity. Changes in CD8+CD28- T cell percentages may thus assist in the early differential diagnosis of pSS patients from those with similar clinical symptoms. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：143 / 151
页数：9
相关论文
共 30 条
  • [1] Clinical features of Sjogren's syndrome in patients with multiple sclerosis
    Annunziata, P.
    De Santi, L.
    Di Rezze, S.
    Millefiorini, E.
    Capello, E.
    Mancardi, G.
    De Riz, M.
    Scarpini, E.
    Vecchio, R.
    Patti, F.
    [J]. ACTA NEUROLOGICA SCANDINAVICA, 2011, 124 (02): : 109 - 114
  • [2] CD8+CD28- T cells:: Certainties and uncertainties of a prevalent human T-cell subset
    Arosa, FA
    [J]. IMMUNOLOGY AND CELL BIOLOGY, 2002, 80 (01) : 1 - 13
  • [3] Modulation of CD28 expression with anti-tumor necrosis factor α therapy in rheumatoid arthritis
    Bryl, E
    Vallejo, AN
    Matteson, EL
    Witkowski, JM
    Weyand, CM
    Goronzy, JJ
    [J]. ARTHRITIS AND RHEUMATISM, 2005, 52 (10): : 2996 - 3003
  • [4] Advancements on phenotypic and functional characterization of non-antigen-specific CD8+CD28-regulatory T cells
    Fenoglio, Daniela
    Ferrera, Francesca
    Fravega, Marco
    Balestra, Piercesare
    Battaglia, Florinda
    Proietti, Michele
    Andrei, Cristina
    Olive, Daniel
    Antonio, La Cava
    Indiveri, Francesco
    Filaci, Gilberto
    [J]. HUMAN IMMUNOLOGY, 2008, 69 (11) : 745 - 750
  • [5] CD8+ T regulatory/suppressor cells and their relationships with autoreactivity and autoimmunity
    Filaci, Gilberto
    Fenoglio, Daniela
    Indiveri, Francesco
    [J]. AUTOIMMUNITY, 2011, 44 (01) : 51 - 57
  • [6] CD4+CD28-T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients
    Gerli, R
    Schillaci, G
    Giordano, A
    Bocci, EB
    Bistoni, O
    Vaudo, G
    Marchesi, S
    Pirro, M
    Ragni, F
    Shoenfeld, Y
    Mannarino, E
    [J]. CIRCULATION, 2004, 109 (22) : 2744 - 2748
  • [7] Clinical manifestations of neurological involvement in primary Sjogren's syndrome
    Gono, Takahisa
    Kawaguchi, Yasushi
    Katsumata, Yasuhiro
    Takagi, Kae
    Tochimoto, Akiko
    Baba, Sayumi
    Okamoto, Yuko
    Ota, Yuko
    Yamanaka, Hisashi
    [J]. CLINICAL RHEUMATOLOGY, 2011, 30 (04) : 485 - 490
  • [8] Detection of circulating soluble CD28 in patients with systemic lupus erythematosus, primary Sjogren's syndrome and systemic sclerosis
    Hebbar, M
    Jeannin, P
    Magistrelli, G
    Hatron, PY
    Hachulla, E
    Devulder, B
    Bonnefoy, JY
    Delneste, Y
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 136 (02) : 388 - 392
  • [9] Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
    Hochberg, MC
    [J]. ARTHRITIS AND RHEUMATISM, 1997, 40 (09): : 1725 - 1725
  • [10] T lymphocytes in patients with primary vasculitis:: expansion of CD8+ T cells with the propensity to activate polymorphonuclear neutrophils
    Iking-Konert, C.
    Vogl, T.
    Prior, B.
    Wagner, C.
    Sander, O.
    Bleck, E.
    Ostendorf, B.
    Schneider, M.
    Andrassy, K.
    Haensch, G. M.
    [J]. RHEUMATOLOGY, 2008, 47 (05) : 609 - 616
123